The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins
about
Crystal structure of the Golgi casein kinaseIdentification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycansA Single Kinase Generates the Majority of the Secreted PhosphoproteomeSecreted protein kinasesA unified model for bone-renal mineral and energy metabolismThe secretory pathway kinasesThe calcified eggshell matrix proteome of a songbird, the zebra finch (Taeniopygia guttata)PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolismSpecific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.The specific role of FAM20C in amelogenesisThe specific role of FAM20C in dentinogenesis.Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice.A novel predicted calcium-regulated kinase family implicated in neurological disorders.Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysisPhosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 ActivationVariability of systemic and oro-dental phenotype in two families with non-lethal Raine syndrome with FAM20C mutations.High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.Proteomic analysis of quail calcified eggshell matrix: a comparison to chicken and turkey eggshell proteomes.Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes.Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in boneFGF23 is endogenously phosphorylated in bone cells.Systemic Control of Bone Homeostasis by FGF23 Signaling.FAM20A binds to and regulates FAM20C localizationPhosphorylation of spore coat proteins by a family of atypical protein kinases.Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects.The proteome of the calcified layer organic matrix of turkey (Meleagris gallopavo) eggshell.Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.The rachitic tooth.Phosphorylation of substrates destined for secretion by the Fam20 kinases.Raine Syndrome (OMIM #259775), Caused By FAM20C Mutation, Is Congenital Sclerosing Osteomalacia With Cerebral Calcification (OMIM 259660).Systematic network-based discovery of a Fam20C inhibitor (FL-1607) with apoptosis modulation in triple-negative breast cancer.The generation of phosphoserine stretches in phosphoproteins: mechanism and significance.Casein kinases as potential therapeutic targets.Fam20C is under the control of sphingolipid signaling in human cell lines.Extracellular Protein Phosphorylation, the Neglected Side of the Modification.Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Amelogenesis Imperfecta; Genes, Proteins, and Pathways.
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P2860
The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins
description
2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@ast
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@en
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@nl
type
label
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@ast
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@en
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@nl
prefLabel
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@ast
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@en
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@nl
P2093
P2860
P921
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P1476
The Raine syndrome protein FAM ...... es bio-mineralization proteins
@en
P2093
Hiroyuki O Ishikawa
Kenneth D Irvine
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0042988
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P577
2012-01-01T00:00:00Z