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MAP3K3:SQSTM1K48polyUB Mitophagy Substrates:SQSTM1Ubiquitinated NRIF:SequestosomeUbiquitinated NRIF:Sequestosome [nucleoplasm]NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-betap62 binds ubiquitinated mitochondrial substratesPolyubiquitinated NRIF binds to p62 (Sequestosome)p62 is recruited and forms a complex with TRAF6
P527
P688
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagyComprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein networkTRIM proteins regulate autophagy and can target autophagic substrates by direct recognitionp62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bonep62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcriptionp62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteinsp62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagyMolecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domainEssential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosisPhosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal regionA directed protein interaction network for investigating intracellular signal transductionLRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular modelHuntingtin functions as a scaffold for selective macroautophagyAn ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport.WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins
P921
Q50262661-00575A85-5773-4465-B0CB-4BE1C1F0D1B6Q50269774-92486A05-AE5E-4BAB-A840-F7F2108F0A40Q50271219-A5879E47-B590-4879-8362-96ABE5BE79E4Q50271222-4FCD22C8-0599-46D0-84E0-C3EABDC7BF99Q50271261-842C438F-0D51-468C-BF10-CAC0D06DE8E3Q50271262-34025BE8-223B-4821-A737-4AD55436E494Q50271269-8D5B8445-22DA-4D11-92BE-808DB0D0EF1AQ50296960-367BA1BE-40DA-481C-9A91-3E1B7DE31193Q50297695-2C05BD17-F2C2-4761-988A-C452DBB9F9E5Q50297695-E387DEA3-2714-41E2-B383-984CC5FBC519Q50297713-D256F02C-A819-43CB-9C7E-845DE3433CBB
P527
Q24300134-FE3753E2-6CFD-4ADC-8E57-DA498DB748D5Q24301939-1D75DC11-E733-472C-81FB-3E32A53A8521Q24302068-A53FC39C-654B-4648-B9B5-17BD457041CEQ24305232-7DF36B76-743B-45AB-B824-630F0EFB4F89Q24307892-3F306A00-E470-41ED-BAB6-1F90CA1F8519Q24310885-1F7DFE67-0DB6-448D-9022-B05E23BFF379Q24311839-3B7C2B3B-28F4-4213-849B-C83F6439196EQ24312147-A636EF42-6A35-46DA-9BF3-9010DF61AE7CQ24316893-864248BD-0F40-453D-B414-A1B85BD52A6FQ24323246-96AEE49D-0B3C-461E-81EC-13DA0F87BA0CQ24336479-EE249476-6EEF-4FA0-ACEF-E1302E0E50BDQ24337382-1F842A74-67F4-4E2F-A487-AAE6D5461092Q24656256-9902EC44-1672-4AA5-88D5-6FC7240BAB37Q28118022-BC6E3106-E8D6-4C56-8F0C-05F3C1851D01Q29871467-212C7300-9D64-4897-BD0B-5C11529D7C66Q30090184-291DDDD4-73B1-437A-9167-4A0F425756A7Q34297536-95CE421F-7B9D-46F7-A185-FA7275106375Q38839499-398DE877-6C81-4038-ADB4-18B9F60062ABQ51111629-1E317757-1FC1-4D24-A382-35E246881746
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Sequestosome 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
Sequestosome 1
@en
Sequestosome 1
@nl
type
label
Sequestosome 1
@en
Sequestosome 1
@nl
altLabel
EBI3-associated protein of 60 kDa
@en
EBI3-associated protein p60
@en
EBIAP
@en
SQSTM1
@en
autophagy receptor p62
@en
oxidative stress induced like
@en
p60
@en
phosphotyrosine independent ligand for the Lck SH2 domain p62
@en
phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
@en
sequestosome-1
@en
prefLabel
Sequestosome 1
@en
Sequestosome 1
@nl
P527
P637
P638
P680
P681
P682
P705
P352
P486
P31
P352
P486
D000071456
P527
P637
NP_001135770
NP_001135771
P638
P680
P681
P682
P702
P703
P705
ENSP00000353944
ENSP00000374455
ENSP00000394534
ENSP00000405061
ENSP00000424195
ENSP00000424477
ENSP00000425957
ENSP00000427308
ENSP00000487071
ENSP00000491834