about
sameAs
BRAF ser-445 ser-729 phosphorylatedBRAF ser-445 ser-729 ser-599 ser-602 phosphorylatedL-valine 600 replaced with L-glutamic acidglycine 469 replaced with L-alanineL-glutamic acid 586 replaced with L-lysine ser-445 ser-729 phosphorylatedL-phenylalanine 595 replaced with L-leucine ser-445 ser-729 phosphorylatedglycine 464 replaced with L-glutamic acid ser-445 ser-729 phosphorylatedL-leucine 597 replaced with L-valine ser-445 ser-729 phosphorylatedL-valine 600 replaced with L-lysine ser-445 ser-729 phosphorylatedL-glutamic acid 586 replaced with L-lysine ser-445 ser-729 ser-599 ser-602 phosphorylatedL-phenylalanine 595 replaced with L-leucine ser-445 ser-729 ser-599 ser-602 phosphorylatedglycine 464 replaced with L-glutamic acid ser-445 ser-729 ser-599 ser-602 phosphorylatedL-leucine 597 replaced with L-valine ser-445 ser-729 ser-599 ser-602 phosphorylatedL-valine 600 replaced with L-lysine ser-445 ser-729 ser-599 ser-602 phosphorylatedL-aspartic acid 594 replaced with glycineL-aspartic acid 594 replaced with L-asparagineL-aspartic acid 594 replaced with L-valineglycine 466 replaced with L-glutamic acidglycine 596 replaced with L-arginineBRAF ser-365 ser-445 ser-729 phosphorylatedBRAF ser-445 ser-729 ser-599 ser-602 ser-151 ser-750 ser-753 ser-401 phosphorylatedBRAF ser-338 phosphorylatedBRAF ser-unknown ser-unknown phosphorylatedBRAF ser-445 ser-729 phosphorylated [cytosol]L-valine 600 replaced with L-glutamic acid [cytosol]V600E BRAF V169_M438del [cytosol]V600E BRAF V47_D380del [cytosol]V600E BRAF V47_M438del [cytosol]BRAF ser-445 ser-729 ser-599 ser-602 phosphorylated [cytosol]
P279
'activator' RAFsV600E BRAF splice variantsmoderate kinase activity BRAF mutantsphosphorylated moderate kinase activity BRAF mutantsWT BRAF:inhibitorskinase dead BRAF mutantsinactive RAFsdephosphorylated inactive RAFsactivated RAF monomerRasGTP-B raf compexSPRY2:B-RAFS111/S120 p-SPRY2:B-RAFB-RAFBRAF complexB-RAF dissociates from S111/S120 p-SPRY2
P527
P688
Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signalingThe amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.Stimulation of the Na(+)-coupled glucose transporter SGLT1 by B-RAFNilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemiaStructure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signalingDi-Ras, a distinct subgroup of ras family GTPases with unique biochemical propertiesIQGAP1 modulates activation of B-RafDistinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signallingEndothelial apoptosis in Braf-deficient miceIdentification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylationIQGAP1 integrates Ca2+/calmodulin and B-Raf signalingCrystal structure of a BRAF kinase domain monomer explains basis for allosteric regulationA dimerization-dependent mechanism drives RAF catalytic activation.Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.MEK drives BRAF activation through allosteric control of KSR proteins.
P921
Q50369896-13BD4906-069D-4237-AA5A-F0A8187D06B6Q50369899-17486FB2-6854-492A-98D2-DED3A54861EDQ50369904-E139E792-F088-4468-B068-30952647BB9FQ50369905-99A51991-86C5-4CBB-BB97-79E0F0EF57EDQ50369913-9ADAFED9-6AB9-444E-B4CB-420BFA864D3BQ50369914-569EBFAB-213A-4DF6-A641-ADBD10CCD737Q50369915-7DA99723-8B26-4879-A201-31795972ADCBQ50369916-F3292D6B-7FEC-4F51-B1A1-3C41D1B45EE8Q50369917-C7070F94-E62B-435E-9570-38957D0748F0Q50369919-1B0B6AFA-ACB2-4C8B-B6C8-232AAF7E31A5Q50369920-754F83D4-554C-486C-B61C-318CAAFD8CE3Q50369921-E505B747-A738-442F-8168-0328F4B21935Q50369922-61DE3C3A-F066-41A1-99BD-A1A5F61B982CQ50369924-14340247-34EF-4AA0-BC72-0EA89B1B3D8FQ50369925-7FE672C5-4297-47AE-8743-CD05BEE8C69CQ50369926-4DC195AD-8B6C-4AA3-8344-4CE072345D38Q50369927-D49B167A-A946-40AE-B311-420E870066B1Q50369928-7C85E62E-D751-459B-B7BD-B7767C64E411Q50369929-41030FF7-0596-4AD6-9ECE-225469499EC0Q50372446-D0BE1515-1FD0-4F32-A5D5-E1E4D1168994Q50372453-419E3304-0219-415F-982F-5958904FD8D1Q50373983-FBA63757-B0E2-4530-9828-A17F8420974EQ50374057-18C20D79-CD50-45F6-90BE-87BA5C7C9919Q50677294-B95ADB62-B84A-4B12-92B9-9D86DBBE8130Q50677295-88A572E0-51EB-47D7-9368-6F94D9F03CA8Q50684288-C171CF8C-8D89-4361-97B4-5719486C4EC7Q50684289-82B4FCEC-B0EC-45BD-8088-45E94A0C4A25Q50684290-8FDCD701-D5A8-4BA6-BBB3-1591C6A44BB1Q56838032-6FA66E27-9BFD-4456-8194-D3BCE5CB63DE
P279
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in BRAF
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
B-Raf proto-oncogene, serine/threonine kinase
@en
BRAF (ген)
@uk
BRAF
@nl
BRAF
@pt
kinaza seroninowo-treoninowa BRAF
@pl
type
label
B-Raf proto-oncogene, serine/threonine kinase
@en
BRAF (ген)
@uk
BRAF
@nl
BRAF
@pt
kinaza seroninowo-treoninowa BRAF
@pl
altLabel
94 kDa B-raf protein
@en
B-Raf proto-oncogene serine/threonine-protein kinase (p94)
@en
B-Raf serine/threonine-protein
@en
BRAF
@en
murine sarcoma viral (v-raf) oncogene homolog B1
@en
p94
@en
proto-oncogene B-Raf
@en
serine/threonine-protein kinase B-raf
@en
v-raf murine sarcoma viral oncogene homolog B
@en
v-raf murine sarcoma viral oncogene homolog B1
@en
prefLabel
B-Raf proto-oncogene, serine/threonine kinase
@en
BRAF (ген)
@uk
BRAF
@nl
BRAF
@pt
kinaza seroninowo-treoninowa BRAF
@pl
P129
P527
P637
P638
P680
P681
P682
P705
P352
P637
P31
P352
P527
P637
NP_001341538
NP_001361173
NP_001361187
NP_001365396
NP_001365397
NP_001365398
NP_001365399
NP_001365400
NP_001365401
NP_001365402
P638
P680
P681
P682
P702
P703
P705
ENSP00000288602
ENSP00000418033
ENSP00000419060
ENSP00000420119
ENSP00000493543
ENSP00000493678
ENSP00000493783
ENSP00000494784
ENSP00000495132
ENSP00000495858