SRC proto-oncogene, non-receptor tyrosine kinase

SRC proto-oncogene, non-receptor tyrosine kinase

Item
http://www.wikidata.org/entity/Q21109354
Protein kinase-like domain superfamilySH3-like domain superfamilySH2 domain superfamilySRC-1; PTK2SRC;FYNSRC;FYN;YES;LYNSRC-1; RAP1GAPMyrG-p-Y419-SRC;MyrG-p-Y426-YES1Activated PAR1:Beta-arrestin-1:Src:ERKActivated PAR1:Beta-arrestin-2:Src:ERKActivated PAR1:Beta-arrestin-1:Activated Src:ERKActivated PAR1:Beta-arrestin-1:Activated Src:Activated ERKSrc family tyrosine kinases (SFKs)Src family kinases (SFKs)VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y;S732-PTK2:SRC-1:HSP90AA1VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y;S732-PTK2:SRC-1:HSP90AA1VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1p-Y419/420/426-N-myristoyl-SRC/FYN/YES1RHOD:GTP:DIAPH2:SRC-1Cx43:ZO-1:c-src hemi-channelphospho-Y265 Cx43:ZO-1 gap junctionc-src associated cx43 hemi-channelPhosphorylation of FAK by Src kinasePhosphorylation of L1 by SRCGP1b signaling involves c-SrcSrc activation following P2Y purinoceptor activationBeta-arrestin-1 acts as scaffold for a PAR1 signalling complexBeta-arrestin-2 acts as scaffold for a PAR1 signalling complexAutophosphorylation of SRCSRC kinase phosphorylates CLEC7A:1;3-beta-D-glucanp-S13; FUNDC1 is phosphorylated by CK2 at Tyr18Phosphorylation of EGFR by SRC kinaseSRC phosphorylates SPRY2 on Y55 and Y227SRC-1 autophosphorylatesSRC-1 phosphorylates SHBSRC-1 binds p-Y397-PTK2SRC1-1 binds SH2D2A and is recruited to VEGFR2SFKs phosphorylate PLCG1
P527
SRC
P688
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexesThe beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptorRegulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stressTissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cellsRegulation of cytochrome c oxidase activity by c-Src in osteoclastsSrc kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasmExpression and function of RANK in human monocyte chemotaxisNitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertensionAutotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodiaCrosstalk between Src and major vault protein in epidermal growth factor-dependent cell signallingThe adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factorsHeme controls the regulation of protein tyrosine kinases Jak2 and SrcIntegrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexesIdentification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cellsTUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signalingEphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxisA novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathwaysA novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent mannerGbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activationCooperation between integrin alphavbeta3 and VEGFR2 in angiogenesisActivation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cellsPKCdelta-dependent functional switch of rpS3 between translation and DNA repairAssociation of Src tyrosine kinase with a human potassium channel mediated by SH3 domainIntegrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor βThe Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 associationInterchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular functionVav2 is required for cell spreadingSteel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cellsGab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-KitPituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiationIdentification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behaviorTyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factorsKit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferationSPAP2, an Ig family receptor containing both ITIMs and ITAMsLipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectinJNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling.VE-cadherin facilitates BMP-induced endothelial cell permeability and signalingReversion-induced LIM interaction with Src reveals a novel Src inactivation cycle
P921

SRC proto-oncogene, non-receptor tyrosine kinase

Item
http://www.wikidata.org/entity/Q21109354
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
在智人中發現的哺乳動物蛋白質
@zh
name
C-Src
@fa
SRC proto-oncogene, non-receptor tyrosine kinase
@en
SRC proto-oncogene, non-receptor tyrosine kinase
@nl
SRC激酶
@zh
Src
@cs
Src
@tr
Tyrosinkinase Src
@de
type
label
C-Src
@fa
SRC proto-oncogene, non-receptor tyrosine kinase
@en
SRC proto-oncogene, non-receptor tyrosine kinase
@nl
SRC激酶
@zh
Src
@cs
Src
@tr
Tyrosinkinase Src
@de
altLabel
SRC
@en
p60-Src
@en
pp60c-src
@en
proto-oncogene c-Src
@en
proto-oncogene tyrosine-protein kinase Src
@en
protooncogene SRC, Rous sarcoma
@en
tyrosine kinase pp60c-src
@en
tyrosine-protein kinase SRC-1
@en
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
@en
prefLabel
C-Src
@fa
SRC proto-oncogene, non-receptor tyrosine kinase
@en
SRC proto-oncogene, non-receptor tyrosine kinase
@nl
SRC激酶
@zh
Src
@cs
Src
@tr
Tyrosinkinase Src
@de
P129
P18
P31
P352
P361
P486
P527
P591
P6366
P637
P638
P680
P681
P682
P702
P703
P705
P7260
P352
P486
P6366
P637
P638
P129
P18
P31
P352
P361
P486
P527
P591
P6366
P637
P638
P680
P681
P682
P702
P703
P705
P7260