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DNA DSBs:p-MRN:p-S1981;Ac-K3016-ATM:KAT5:K63PolyUb-K14;K16;p-S139-H2AFX;Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4DNA DSBs:p-MRN:p-S1981;Ac-K3016-ATM:KAT5:p-S139-H2AFX;Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A;B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4DNA DSBs:p-MRN:p-S1981;Ac-K3016-ATM:KAT5:K63PolyUb-K14;K16;p-S139-H2AFX;Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A;B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4DNA DSBs:p-MRN:p-S1981;Ac-K3016-ATM:KAT5:K63PolyUb-K14;K16;p-S139-H2AFX;Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840;p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4SUMO1:RNF168RNF168 binds DNA DSBsRNF4 ubiquitinates MDC1Association of Ku heterodimer with ends of DNA double-strand breakPIAS4 SUMOylates RNF168 with SUMO1
P527
P688
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signalingThe E3 ligase RNF8 regulates KU80 removal and NHEJ repairUMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathwayRNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesThe RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damageRNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsDNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc fingerRNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AXATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaksA ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair networkTandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaksThe histone demethylase LSD1/KDM1A promotes the DNA damage response53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
P921
Q50250547-A041AAE0-651A-4AD6-9C02-91ACC8304D67Q50253453-4B613AD3-E8B2-4D61-BF29-D209F783B098Q50253455-C8B6FB07-3052-42BC-A317-370D6379FC58Q50253485-91161215-2A2E-44EB-B1C9-D1CD1C2E7AF7Q50268706-CBE59946-DE6F-4754-8401-C4B40B0BEDD7Q50287328-BAF55AFF-8636-4807-A800-72AC4C386AF6Q50287343-2CD80E38-4EDA-4678-820C-81B8493A490FQ50287399-F096385B-7013-42B9-A019-8CF2A4C99522Q50296443-DD59E3D8-9569-4279-94B7-D001181FAC35
P527
Q24298746-2754BAD0-EB52-4A16-9C5C-B8D98D9FFDCCQ24302499-26558317-9581-478E-A4AF-EE010FEA5914Q24305173-1A72B91E-A266-4CBD-85EE-A9F3163DA626Q24306486-8BCD82DB-EE68-4B18-8941-A4C0548DC74AQ24309181-403606E2-F175-4229-BBA4-C2682EACC328Q24309287-BC1ED366-D051-409D-A043-D56590777DF3Q24314513-9B303E74-D6BB-4BF1-B4CD-F55952AA2AD1Q24317544-41064BD0-CD98-4ED9-9C99-5C8CE920BB9CQ24321489-E9F091F8-6641-4E87-9625-AFF49D10908AQ24338452-17C6168E-B7B6-4D1B-A3B6-FAB008E14DE2Q24339324-7A86A67A-B6A1-4A7A-AD58-F041F2340407Q24339556-98DFF6B9-CE74-4FD5-AE4B-715B45E48E77Q29465773-6CAB8FF4-5020-4B0E-AD88-D9FB3771F67D
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in Ring finger protein 168
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
Ring finger protein 168
@en
type
label
Ring finger protein 168
@en
altLabel
E3 ubiquitin-protein ligase RNF168
@en
RING finger protein 168
@en
RING-type E3 ubiquitin transferase RNF168
@en
RNF168
@en
ring finger protein 168, E3 ubiquitin protein ligase
@en
prefLabel
Ring finger protein 168
@en
P680
P681
P682
P352
P637
P279
P31
P352
P637
P680
P681
P682
P702
P703
P705
ENSP00000320898
ENSP00000396712