Molecular architecture of human polycomb repressive complex 2 - Test2 - elhamkhani - TriplyDB

Molecular architecture of human polycomb repressive complex 2

Molecular architecture of human polycomb repressive complex 2

http://www.wikidata.org/entity/Q21128799

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LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer Uncertainty in integrative structural modeling Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2 EZH2 in Bladder Cancer, a Promising Therapeutic Target Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put A dimeric state for PRC2 Cross-linking immunoprecipitation-MS (xIP-MS): Topological Analysis of Chromatin-associated Protein Complexes Using Single Affinity Purification.Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation.Molecular architecture of polycomb repressive complexes The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1.The central role of EED in the orchestration of polycomb group complexes.Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2 EZH2: biology, disease, and structure-based drug discovery Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy.The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.AEBP2 as a transcriptional activator and its role in cell migration Understanding the relationship between DNA methylation and histone lysine methylation.Structural insights into binding of small molecule inhibitors to Enhancer of Zeste Homolog 2.Histones: at the crossroads of peptide and protein chemistry.Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity.Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells.Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging.Targeting EZH2 and PRC2 dependence as novel anticancer therapy.Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC.Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells.Protein domain mapping by internal labeling and single particle electron microscopy.The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation Cross-species Analyses Unravel the Complexity of H3K27me3 and H4K20me3 in the Context of Neural Stem Progenitor Cells.Structural analysis of an active fungal PRC2.Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

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Alessio Maiolica

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Franz Herzog

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Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.

Structural basis of EZH2 recognition by EED

Role of the polycomb protein EED in the propagation of repressive histone marks

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

Histone methylation by PRC2 is inhibited by active chromatin marks

Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z)12 through Partially Overlapping Binding Sites

UCSF Chimera--a visualization system for exploratory research and analysis

Accurate determination of local defocus and specimen tilt in electron microscopy

EMAN2: an extensible image processing suite for electron microscopy

A new generation of the IMAGIC image processing system

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Claudio Ciferri

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