Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2 - Test2 - elhamkhani - TriplyDB

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

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Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy Chemical Tools for Dissecting the Role of lncRNAs in Epigenetic Regulation A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading Capitalizing on disaster: Establishing chromatin specificity behind the replication fork.Molecular architecture of polycomb repressive complexes Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana.RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes.Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer.Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis.Hyperhomocysteinemia in ApoE-/- Mice Leads to Overexpression of Enhancer of Zeste Homolog 2 via miR-92a Regulation.Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.Structural analysis of an active fungal PRC2.Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.Normal chromosome conformation depends on subtelomeric facultative heterochromatin in Neurospora crassa Touch, act and go: landing and operating on nucleosomes.A Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi.The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.Polycomb repressive complex 2 in an autoinhibited state.Inhibitors of Protein Methyltransferases and Demethylases.An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.Mechanisms of Nucleosome Dynamics In Vivo.Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.Oncogenic Mechanisms of Histone H3 Mutations.The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".A chemical probe toolbox for dissecting the cancer epigenome.Structure of the PRC2 complex and application to drug discovery.Recent progress in developing selective inhibitors of protein methyltransferases.Cancer stem cells and epithelial-mesenchymal transition in urothelial carcinoma: Possible pathways and potential therapeutic approaches.

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Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

http://www.wikidata.org/entity/Q27702306

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2015 nî lūn-bûn

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2015 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2015年の論文

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Structural basis of histone H3 ...... polycomb repressive complex 2

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Molecular architecture of human polycomb repressive complex 2

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Processing of X-ray diffraction data collected in oscillation mode

Structural basis of EZH2 recognition by EED

Role of the polycomb protein EED in the propagation of repressive histone marks

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

Histone methylation by PRC2 is inhibited by active chromatin marks

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