Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two steps
about
RTX proteins: a highly diverse family secreted by a common mechanismBacterial Toxins as Pathogen Weapons Against PhagocytesCalcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretionAdenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacityPresence of Bacterial Virulence Gene Homologues in the dibenzo-p-dioxins degrading bacterium Sphingomonas wittichiiBordetella adenylate cyclase toxin interacts with filamentous haemagglutinin to inhibit biofilm formation in vitro.The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.Exposure to host ligands correlates with colocalization of Gal/GalNAc lectin subunits in lipid rafts and phosphatidylinositol (4,5)-bisphosphate signaling in Entamoeba histolytica.Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen-presenting cells by the Bordetella RTX hemolysin moiety lacking the adenylyl cyclase domain.Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussisCalpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain.The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapseCalcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic formBordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayerAggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association.Breaking in and grabbing a meal: Anaplasma phagocytophilum cellular invasion, nutrient acquisition, and promising tools for their study.Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines.Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.Phospholipase A activity of adenylate cyclase toxin mediates translocation of its adenylate cyclase domain.Inhibition of Bacterial Toxin Activity by the Nuclear Stain, DRAQ5™Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin.Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin.Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.Inhibition of LtxA toxicity by blocking cholesterol binding with peptides.The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin.In silico detection of virulence gene homologues in the human pathogen sphingomonas spp.Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes.Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes.Bordetella pertussis adenylate cyclase toxin disrupts functional integrity of bronchial epithelial layers.Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.Microbes at their best: first Mol Micro Meeting Würzburg.Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8+ and CD4+ T cells.cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain.Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane VesiclesMembrane localization of the Repeats-in-Toxin (RTX) Leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitans
P2860
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P2860
Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two steps
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@ast
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@en
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@en-gb
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@nl
type
label
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@ast
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@en
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@en-gb
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@nl
altLabel
Bordetella Adenylate Cyclase T ...... get Cell Membrane in Two Steps
@en
prefLabel
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@ast
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@en
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@en-gb
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@nl
P2860
P1433
P1476
Bordetella adenylate cyclase t ...... get cell membrane in two steps
@en
P2093
Jiri Masin
Ladislav Bumba
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000901
P407
P577
2010-05-01T00:00:00Z