An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
about
Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two stepsSub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complexControl of PKA stability and signalling by the RING ligase praja2Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferationIloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humansAKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complexSelective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMPThe genetically encoded tool set for investigating cAMP: more than the sum of its partsCaV1.2 signaling complexes in the heartCompartmentalization of β-adrenergic signals in cardiomyocytesDynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexesAKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systemsNon-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoformsSmall molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytesPGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.Drug screening in a zebrafish model of Duchenne muscular dystrophy.[EXPRESS] Epac and Nociceptor Sensitization.Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes.Tilapia hepcidin 2-3 peptide modulates lipopolysaccharide-induced cytokines and inhibits tumor necrosis factor-alpha through cyclooxygenase-2 and phosphodiesterase 4DCalcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.Zebrafish based small molecule screens for novel DMD drugs.PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblastsEPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.Emerging Roles for SSeCKS/Gravin/AKAP12 in the Control of Cell Proliferation, Cancer Malignancy, and Barriergenesis.Pseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells.Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascadeAKAP5 and AKAP12 Form Homo-oligomers.Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseAKAP12 and AKAP5 form higher-order hetero-oligomers.Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.Cyclic AMP Regulates Social Behavior in African Trypanosomes.Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction NetworkAssessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.Involvement of Src family of kinases and cAMP phosphodiesterase in the luteinizing hormone/chorionic gonadotropin receptor-mediated signaling in the corpus luteum of monkey.cAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle.Estimating the magnitude of near-membrane PDE4 activity in living cells
P2860
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P2860
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@ast
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@en
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@en-gb
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@nl
type
label
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@ast
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@en
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@en-gb
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@nl
prefLabel
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@ast
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@en
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@en-gb
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@nl
P2093
P2860
P3181
P356
P1433
P1476
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
@en
P2093
Debbie Willoughby
Dermot M F Cooper
Jerome Schaack
John D Scott
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601113
P407
P577
2006-05-17T00:00:00Z