Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole
about
Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesComputer aided enzyme design and catalytic conceptsTesting Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleHydrogen Bond Coupling in the Ketosteroid Isomerase Active SiteDissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion holeStructural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active siteAt the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Computational protein engineering: bridging the gap between rational design and laboratory evolution.Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.Predicting the photoinduced electron transfer thermodynamics in polyfluorinated 1,3,5-triarylpyrazolines based on multiple linear free energy relationshipsKemp Eliminase Activity of Ketosteroid Isomerase.Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization.Proton affinity of the oxyanion hole in the active site of ketosteroid isomerase.Solvation response along the reaction coordinate in the active site of ketosteroid isomerase.Water in the active site of ketosteroid isomerase.On catalytic preorganization in oxyanion holes: highlighting the problems with the gas-phase modeling of oxyanion holes and illustrating the need for complete enzyme models.Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation.Hydrogen bonding in the active site of ketosteroid isomerase: electronic inductive effects and hydrogen bond couplingCo-factor binding confers substrate specificity to xylose reductase from Debaryomyces hansenii.Extreme electric fields power catalysis in the active site of ketosteroid isomeraseA quantitative measure of electrostatic perturbation in holo and apo enzymes induced by structural changesDo ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site.Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.Direct measurement of the protein response to an electrostatic perturbation that mimics the catalytic cycle in ketosteroid isomeraseSite-specific measurement of water dynamics in the substrate pocket of ketosteroid isomerase using time-resolved vibrational spectroscopyDissecting Proton Delocalization in an Enzyme's Hydrogen Bond Network with Unnatural Amino Acids.The role of higher CO-multipole moments in understanding the dynamics of photodissociated carbonmonoxide in myoglobinGround state destabilization from a positioned general base in the ketosteroid isomerase active site.Thermodynamic framework for identifying free energy inventories of enzyme catalytic cycles.Free energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methodsHydrogen bond dynamics in the active site of photoactive yellow proteinDevelopment and application of ab initio QM/MM methods for mechanistic simulation of reactions in solution and in enzymes.Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.Hydrogen-bond stabilization in oxyanion holes: grand jeté to three dimensions.Catalytic efficiency of enzymes: a theoretical analysisComputational Enzyme Design: Advances, hurdles and possible ways forwardQuantum mechanical studies of DNA and LNA.
P2860
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P2860
Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@ast
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@en
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@en-gb
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@nl
type
label
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@ast
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@en
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@en-gb
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@nl
altLabel
Testing Electrostatic Compleme ...... teroid Isomerase Oxyanion Hole
@en
prefLabel
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@ast
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@en
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@en-gb
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@nl
P2093
P2860
P50
P1433
P1476
Testing electrostatic compleme ...... teroid isomerase oxyanion hole
@en
P2093
Brandon Pybus
Corey W Liu
Daniel Herschlag
P2860
P356
10.1371/JOURNAL.PBIO.0040099
P407
P577
2006-03-28T00:00:00Z