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Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion holeDNA-catalyzed sequence-specific hydrolysis of DNAComputational enzyme design approaches with significant biological outcomes: progress and challengesStructure-based activity prediction for an enzyme of unknown functionFormation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMPThe importance of reactant positioning in enzyme catalysis: a hybrid quantum mechanics/molecular mechanics study of a haloalkane dehalogenaseProduct deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediateUroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymesCan sequence determine function?Directed evolution strategies for improved enzymatic performanceEnzymes: An integrated view of structure, dynamics and functionRadical-Mediated Enzymatic PolymerizationsFrom Drosophila to humans: reflections on the roles of the prolyl isomerases and chaperones, cyclophilins, in cell function and diseaseCrystal structure of delta(5)-3-ketosteroid isomerase from Pseudomonas testosteroni in complex with equilenin settles the correct hydrogen bonding scheme for transition state stabilizationAnatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analogElectrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylaseThe crystal structure and mechanism of orotidine 5'-monophosphate decarboxylaseA strategically positioned cation is crucial for efficient catalysis by chorismate mutaseCrystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylaseStructure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partnerTesting Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleStructural Characterization of the Molecular Events during a Slow Substrate–Product Transition in Orotidine 5′-Monophosphate DecarboxylaseMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Conformational sampling, catalysis, and evolution of the bacterial phosphotriesteraseDissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion holeConformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active ConformationThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationA Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pyloriMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding SiteConformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the EnzymeAtomic Resolution Structure of the Orotidine 5'-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISMSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseStructure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+cofactorImpact of scaffold rigidity on the design and evolution of an artificial Diels-AlderaseSub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediateActivity of yeast orotidine-5'-phosphate decarboxylase in the absence of metalsDissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylaseA proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylaseAt the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?A Hypothesis: Life Initiated from Two Genes, as Deduced from the RNA World Hypothesis and the Characteristics of Life-Like Systems
P2860
Q21146064-F7093620-D613-4873-89E3-872B065A49A8Q22122102-CD5E8855-D10E-44C1-8C3A-93AE0A9547F4Q24273262-7662F0C8-8D2D-4495-879A-3AB103CFBB50Q24642801-C5435B2D-4358-49BF-9328-C9B21717B324Q24643971-4DB1C810-47D1-4F79-A519-31E5C82936B6Q24652411-DE697042-C7FE-496E-8EA2-2DCF8A17CA4EQ24654578-5209343B-B8FC-4D99-A257-321405850946Q24658184-1CB5B49A-287D-4302-B9C1-E44D91AAD27BQ24804858-C30EB8B9-17B5-4478-ACB2-7147F5217222Q24815563-34AC3AA3-BCD0-4CA2-BCE5-9BA231C7D420Q25255883-763A0F50-1FD1-495C-B22A-A7BBDF2B6BB7Q26768651-A8618B1E-1EDC-483D-AD33-B0CEFC1E0B1FQ26829060-A09C7492-A5F9-446F-ACED-5B3198A051A5Q27620291-634025FF-AC66-4732-929E-5E6F6CC08100Q27621462-D3F84CD7-7A38-4480-B0FB-8579DDE480D2Q27621473-066CB1DD-471A-4DB5-9254-4D91ABF48F07Q27621476-8AD26D3C-A2F1-4007-88A1-7DEE36B69C72Q27626710-F7B0762E-6E2F-4F54-BBF4-B203A2E91363Q27638988-245C5EDE-B626-4F29-A4DB-39EEB52B83ABQ27646340-47D9F769-8119-4361-BF25-241418F14E8BQ27652268-B8C337A2-4CAB-4550-91C7-E718B14D225AQ27653891-AFA39E49-F111-4E04-8BD0-033BE7051540Q27655450-5C18205E-83B4-4B5E-A849-E7433792AA51Q27658462-F1E80195-2839-4AE6-B326-E898A7DCA4C9Q27658994-7D6E6527-6EE2-4AE4-ABB1-C74B097E1547Q27660430-9A6AC3BA-72BC-4F44-9D19-A30EB42CB856Q27667488-35459423-FB47-4C24-AF2D-AA70270C1A55Q27671530-73DD4C65-A1CF-4B85-A948-B05E6275B9DCQ27672055-89EADFAC-EAA5-40BC-8AF1-D0D9D12B1678Q27674002-D112BED5-B960-439B-A18F-985DAE5B5889Q27676270-0B36EBC8-72E7-4157-ABEF-7F0C75817D54Q27680432-02618B71-6EEF-4C29-93D8-A63EC511D879Q27680779-E382D27F-F773-40FE-A897-CAFB32E7052EQ27683868-09A8AEDF-7A34-492F-AE61-6F1DD8D8A518Q27685401-307F93B5-1686-4B4D-B81A-81ABD762CA1AQ28142026-E43FAB0F-0BC5-4556-96E6-581B3ED6326AQ28235383-D6123722-CFA1-451C-BD29-516EFFADD7FCQ28237207-F3F540CB-A26F-487B-969C-47D60ED67B9CQ28271287-CBFB2AC8-5CE9-4470-BAF3-6305D873C1F6Q28598274-9957652E-8C79-469E-93BD-7C3BADD5DA7A
P2860
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
A proficient enzyme
@ast
A proficient enzyme
@en
A proficient enzyme
@en-gb
A proficient enzyme
@nl
type
label
A proficient enzyme
@ast
A proficient enzyme
@en
A proficient enzyme
@en-gb
A proficient enzyme
@nl
prefLabel
A proficient enzyme
@ast
A proficient enzyme
@en
A proficient enzyme
@en-gb
A proficient enzyme
@nl
P3181
P356
P1433
P1476
A proficient enzyme
@en
P2093
A Radzicka
R Wolfenden
P3181
P356
10.1126/SCIENCE.7809611
P407
P577
1995-01-06T00:00:00Z