about
PARP1;PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNAPARP1;PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAPAR-PARP1;PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAFEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNAAPEX1:FEN1:PCNA:POLD;POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNAAPEX1:FEN1:PCNA:POLD;POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNAAnnealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1;PARP2:FEN1:POLQExtended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1;PARP2:FEN1:POLQExtended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1Removal of remaining FlapRemoval of remaining Flap from the C-strandPARP1;PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP siteFEN1 bound to POLB cleaves displaced DNA strand (flap)PCNA:POLD;POLE:RPA:RFC and FEN1 bind APEX1FEN1 bound to PCNA and APEX1 cleaves flap ssDNAPARP1 or PARP2; FEN1 and POLQ are recruited to MMEJ siteFEN1 cleaves displaced ssDNA flaps during MMEJRemoval of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
P527
P688
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activityArginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determinationOpposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial functionStructural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damageHuman DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesThe characterization of a mammalian DNA structure-specific endonucleaseEssential amino acids for substrate binding and catalysis of human flap endonuclease 1Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I
P921
Q50253188-2E688AD0-9DA9-457B-896A-4A3D7FC0EA81Q50253191-4585A939-FEA3-4C41-A3B6-A08C6E2D1771Q50253193-03A21D90-18DC-4507-81B8-1BA874FA2E51Q50253198-549AFBCE-8671-4E22-B706-82AB71634DE6Q50253208-20E114DF-6F4D-42B6-90C3-BD361EC6B5EFQ50253210-9D49520B-E3E5-46F1-ACFD-40325C8B1E65Q50253615-1B8BFAA8-1AEA-43F4-BE0A-3AD2F5E7C114Q50253621-75E62623-71B8-405A-9855-730E324313BAQ50253627-1F312772-DCF7-49F1-B2F8-FEC7BD565BA8Q50286083-451BE6AC-72E8-43BC-AFA5-A1C4320F50A8Q50286333-00FB5FAB-D325-4E27-A692-607249F646B7Q50287231-895C0B61-8F36-44FC-B525-F58AD9655FC3Q50287236-EC971F14-856C-4D95-B1F6-934617DDFFE1Q50287242-E9E992FC-5F98-4F5B-9B25-6679E0905010Q50287244-22E93F39-56C0-4A62-9E99-AFBC7FB7B575Q50287391-A25D31AC-03A7-4419-993A-98C9FCCDAA01Q50287395-AD22630E-36D6-4749-A39B-058B32C3567BQ50289288-7253878B-2F5B-4883-9C53-2827161E367F
P527
Q22003979-BEC89EF9-53F6-492F-A90D-96F42F99644BQ24296440-3CF0A68B-E366-4CC5-B205-3233EC29EF15Q24306488-F62EFEA7-907D-4224-B196-30CF681DD494Q24312006-29656786-D5A5-4594-B0DD-78EF90FCC3D2Q24312975-67C653C8-8236-4C22-8E6A-C62C359D3024Q24336672-62F43D60-BD84-414C-871C-C8C82B19B82BQ24336892-93E7297D-0B07-40EE-AA2C-9DB5CC03144DQ24337115-3D2C6E34-8DA4-439E-9061-45AE9E769EC9
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in Flap structure-specific endonuclease 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
Flap structure-specific endonuclease 1
@en
type
label
Flap structure-specific endonuclease 1
@en
altLabel
DNase IV
@en
FEN1
@en
MF1
@en
Maturation factor 1
@en
flap endonuclease 1
@en
hFEN-1
@en
maturation factor-1
@en
prefLabel
Flap structure-specific endonuclease 1
@en
P361
P527
P638
P680
P681
P682
P705
P352
P637
P31
P352
P361
P637
P638
P680
P681
P682
P702
P703
P705
ENSP00000305480
ENSP00000445692
ENSP00000460402