Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
about
Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceArginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determinationStructural determinants for substrate binding and catalysis by the structure-specific endonuclease XPGWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkThe DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshiiHuman Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 SuperfamilyStructures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease FamilyWuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1Enzymes and reactions at the eukaryotic DNA replication forkCell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Characterization of FEN-1 from Xenopus laevis. cDNA cloning and role in DNA metabolism.Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiaeOptimization based tumor classification from microarray gene expression data.A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis.Novel function of Rad27 (FEN-1) in restricting short-sequence recombination.The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease.EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae.Functional analysis of point mutations in human flap endonuclease-1 active siteCRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation.Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instabilityFlap Endonuclease 1 Limits Telomere Fragility on the Leading StrandOkazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsAdenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and functionMultiplexed and microparticle-based analyses: quantitative tools for the large-scale analysis of biological systems.Flap endonuclease 1 contributes to telomere stabilityCharacterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development.The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation.Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein-DNA complex crystallization.Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates.Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.Deoxy- and dideoxynucleotide discrimination and identification of critical 5' nuclease domain residues of the DNA polymerase I from Mycobacterium tuberculosis.Dynamic evidence for metal ion catalysis in the reaction mediated by a flap endonuclease.FEN1 ensures telomere stability by facilitating replication fork re-initiationContacts between the 5' nuclease of DNA polymerase I and its DNA substrate.
P2860
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P2860
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@ast
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@en
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@en-gb
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@nl
type
label
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@ast
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@en
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@en-gb
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@nl
prefLabel
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@ast
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@en
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@en-gb
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@nl
P2093
P2860
P356
P1476
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
@en
P2093
P2860
P304
P356
10.1074/JBC.271.16.9173
P407
P577
1996-04-19T00:00:00Z