about
P688
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationVEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR)Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residuesAutophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalizationA novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cellsA single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cellsGremlin is a novel agonist of the major proangiogenic receptor VEGFR2Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factorDecorin causes autophagy in endothelial cells via Peg3Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cellsIntegrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGFThe myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signalingAIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in miceCooperation between integrin alphavbeta3 and VEGFR2 in angiogenesisDifferent signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factorVascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesisVEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cellsDirect contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signalingBiological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptorMicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sitesVascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signalingMiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathwayImatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cellsDownregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.Structure of a VEGF-VEGF receptor complex determined by electron microscopy.Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway.MicroRNA-15b contributes to ginsenoside-Rg1-induced angiogenesis through increased expression of VEGFR-2.Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells
P921
Q15149723-7CC6FEC2-8C98-4DF9-A4B4-D737C0047DC2Q3891664-5D68B0E5-DF45-4095-9188-CDA4DAB68683Q417542-5713F59B-3117-4914-95AC-B81E1AC4A628Q421136-353CE663-448A-499B-9550-0996BE477179Q4830631-B85BE17D-6327-4661-88D1-2448607201CEQ5057052-1C0D1840-267D-4651-973F-CB7F543C2743Q6523413-0793FEE1-C1CD-435F-8003-FC12858E7713Q6554172-2030FFE1-6E48-40AA-832E-591C21AFB733Q6917202-EBF7918E-01C3-4848-8B08-2B1E155B181EQ7157043-263DA7ED-3C3F-479B-88E5-F9FD47AA689CQ7449140-8C37AECB-E418-48CD-ADBC-BCE416E59879Q7810457-F1578BCD-592A-46B9-AA00-A0F15A12782CQ7914515-9ECEDDE4-C52D-46DD-865D-42C2875D998FQ7917084-906C9DB2-6B3D-4D0F-BA8A-6F43081E73BEQ795057-1382DDCB-4078-45E0-A3FB-E7E6FE9CD212
P129
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in Kinase insert domain receptor
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
Kinase insert domain receptor
@en
type
label
Kinase insert domain receptor
@en
altLabel
FLK-1
@en
Fetal liver kinase 1
@en
KDR
@en
fetal liver kinase-1
@en
kinase insert domain receptor (a type III receptor tyrosine kinase)
@en
protein-tyrosine kinase receptor Flk-1
@en
soluble VEGFR2
@en
tyrosine kinase growth factor receptor
@en
vascular endothelial growth factor receptor 2
@en
prefLabel
Kinase insert domain receptor
@en
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ENSP00000263923