Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
about
Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cellsThe zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesisPhosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGFGrb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradationVEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cellsAcquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expressionThe cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysisEtk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathwayEssential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in miceCaveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathwayIntracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxiaA humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft modelsSystems biology of vascular endothelial growth factorsA compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trapDimerization of VEGF receptors and implications for signal transduction: a computational study.Phosphorylated KDR can be located in the nucleus of neoplastic cells.Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis.Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling.Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib: a molecular imaging studyAnchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells.A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells.In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors.Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayersA widely applicable, high-throughput TR-FRET assay for the measurement of kinase autophosphorylation: VEGFR-2 as a prototype.A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1A multi-gene transcriptional profiling approach to the discovery of cell signature markersLeucine motif-dependent tyrosine autophosphorylation of type III receptor tyrosine kinases.The carboxyl terminus controls ligand-dependent activation of VEGFR-2 and its signalingComputational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.Emerging roles of post-translational modifications in signal transduction and angiogenesisPriming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase.Microtubules coordinate VEGFR2 signaling and sorting.Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational ModelVEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivoSrc-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase.The effect of bevacizumab on human malignant melanoma cells with functional VEGF/VEGFR2 autocrine and intracrine signaling loops.Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability.
P2860
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P2860
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Autophosphorylation of KDR in ...... y and receptor internalization
@ast
Autophosphorylation of KDR in ...... y and receptor internalization
@en
Autophosphorylation of KDR in ...... y and receptor internalization
@en-gb
Autophosphorylation of KDR in ...... y and receptor internalization
@nl
type
label
Autophosphorylation of KDR in ...... y and receptor internalization
@ast
Autophosphorylation of KDR in ...... y and receptor internalization
@en
Autophosphorylation of KDR in ...... y and receptor internalization
@en-gb
Autophosphorylation of KDR in ...... y and receptor internalization
@nl
prefLabel
Autophosphorylation of KDR in ...... y and receptor internalization
@ast
Autophosphorylation of KDR in ...... y and receptor internalization
@en
Autophosphorylation of KDR in ...... y and receptor internalization
@en-gb
Autophosphorylation of KDR in ...... y and receptor internalization
@nl
P356
P1433
P1476
Autophosphorylation of KDR in ...... y and receptor internalization
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202478
P407
P577
1999-02-25T00:00:00Z
P5875
P6179
1003107461