The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.
about
Death and resurrection of the human IRGM geneA dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liverAutophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strainsDisruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell deathLocalisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cellsIndependent and population-specific association of risk variants at the IRGM locus with Crohn's diseaseDisruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuolePhosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulenceThe activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondiiHuman IRGM regulates autophagy and cell-autonomous immunity functions through mitochondriaTargeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.Autophagy and pattern recognition receptors in innate immunityAutophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagyCellular and Molecular Connections between Autophagy and InflammationThe gut mucosal immune response to Toxoplasma gondiiThe alternative translational profile that underlies the immune-evasive state of persistence in Chlamydiaceae exploits differential tryptophan contents of the protein repertoireDeterminants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control itIdentification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance systemThe polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18The Evolutionarily Dynamic IFN-Inducible GTPase Proteins Play Conserved Immune Functions in Vertebrates and CephalochordatesStructural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic InfectionsA synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's diseasePhosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiThe CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levelsA Toxoplasma gondii pseudokinase inhibits host IRG resistance proteinsRegulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiEvolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune CellsA family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionHuman IRGM induces autophagy to eliminate intracellular mycobacteriaSequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityThe gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytesRegulation of macrophage motility by Irgm1Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replicationThe E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins.Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma.The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?
P2860
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P2860
The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The interferon-inducible p47 ( ...... mechanism in the human lineage
@nl
The interferon-inducible p47 ( ...... echanism in the human lineage.
@ast
The interferon-inducible p47 ( ...... echanism in the human lineage.
@en
The interferon-inducible p47 ( ...... echanism in the human lineage.
@en-gb
type
label
The interferon-inducible p47 ( ...... mechanism in the human lineage
@nl
The interferon-inducible p47 ( ...... echanism in the human lineage.
@ast
The interferon-inducible p47 ( ...... echanism in the human lineage.
@en
The interferon-inducible p47 ( ...... echanism in the human lineage.
@en-gb
prefLabel
The interferon-inducible p47 ( ...... mechanism in the human lineage
@nl
The interferon-inducible p47 ( ...... echanism in the human lineage.
@ast
The interferon-inducible p47 ( ...... echanism in the human lineage.
@en
The interferon-inducible p47 ( ...... echanism in the human lineage.
@en-gb
P2093
P2860
P3181
P356
P1433
P1476
The interferon-inducible p47 ( ...... echanism in the human lineage.
@en
P2093
Cemalettin Bekpen
Christoph Rohde
Diane M Dunn
Eva Glowalla
Iana Parvanova
Jonathan C Howard
Julia P Hunn
Libby Guethlein
P2860
P2888
P3181
P356
10.1186/GB-2005-6-11-R92
P407
P50
P577
2005-10-31T00:00:00Z