Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
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Telomere dysfunction and chromosome instabilityAging of hematopoietic stem cells: DNA damage and mutations?SOD2 deficiency promotes aging phenotypes in mouse skinThe quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stabilityThe germline/soma dichotomy: implications for aging and degenerative diseaseGammaH2AX and cancerDNA topoisomerase II-dependent control of the cell cycle progression in root meristems of Allium cepa.Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells.Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markersDNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretionThe use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primatesOnset of quiescence following p53 mediated down-regulation of H2AX in normal cells.Four faces of cellular senescence.Role of oxidatively induced DNA lesions in human pathogenesisAging, cellular senescence, and cancerSystemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant TempolSubtelomeric regions in mammalian cells are deficient in DNA double-strand break repair.Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death.H2AX: functional roles and potential applications.Uncovering the geroprotective potential of medicinal plants from the Judea region of Israel.Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin.Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancerAnalysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescenceThe canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damageNampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1.Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.Markers of oxidant stress that are clinically relevant in aging and age-related diseaseFocus on histone variant H2AX: to be or not to be.Intercellular communication of cellular stress monitored by gamma-H2AX induction.Cellular Senescence - its role in cancer and the response to ionizing radiation.STAT3: a central mediator of pulmonary fibrosis?Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration.Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours.Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.The Causal Relationship between DNA Damage Induction in Bovine Lymphocytes and the Fukushima Nuclear Power Plant Accident.Endogenous DNA breaks: gammaH2AX and the role of telomeres.Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis.Persistent amplification of DNA damage signal involved in replicative senescence of normal human diploid fibroblasts
P2860
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P2860
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Both telomeric and non-telomer ...... mammalian cellular senescence
@ast
Both telomeric and non-telomer ...... mammalian cellular senescence
@en
Both telomeric and non-telomer ...... mammalian cellular senescence
@en-gb
Both telomeric and non-telomer ...... mammalian cellular senescence
@nl
type
label
Both telomeric and non-telomer ...... mammalian cellular senescence
@ast
Both telomeric and non-telomer ...... mammalian cellular senescence
@en
Both telomeric and non-telomer ...... mammalian cellular senescence
@en-gb
Both telomeric and non-telomer ...... mammalian cellular senescence
@nl
prefLabel
Both telomeric and non-telomer ...... mammalian cellular senescence
@ast
Both telomeric and non-telomer ...... mammalian cellular senescence
@en
Both telomeric and non-telomer ...... mammalian cellular senescence
@en-gb
Both telomeric and non-telomer ...... mammalian cellular senescence
@nl
P2093
P2860
P356
P1476
Both telomeric and non-telomer ...... mammalian cellular senescence
@en
P2093
Asako J Nakamura
Izumi Horikawa
Karen S Hathcock
Olga A Sedelnikova
William M Bonner
Y Jeffrey Chiang
P2860
P2888
P356
10.1186/1756-8935-1-6
P407
P577
2008-01-01T00:00:00Z
P5875
P6179
1049901639