A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
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Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage responseDouble strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG islandBoth telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescenceCK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage responseBRCA2 and homologous recombinationBRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complexMDC1 is a mediator of the mammalian DNA damage checkpointWild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairRNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyATM-dependent phosphorylation of ATF2 is required for the DNA damage responseAIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AXDepletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cellsThe phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repressionConcordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatinHighlight: BRCA1 and BRCA2 proteins in breast cancerCellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpointsMERIT40 facilitates BRCA1 localization and DNA damage repairCCDC98 targets BRCA1 to DNA damage sitesE3 ubiquitin ligase COP1 regulates the stability and functions of MTA1VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damageUV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalizationInternal IgH class switch region deletions are position-independent and enhanced by AID expressionA DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damageActivation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chainsPhosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phaseDeficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stressArtemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint responseChk2 phosphorylation of BRCA1 regulates DNA double-strand break repairEpigenetic modifications in double-strand break DNA damage signaling and repairMus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cellsRequirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C MutationThe mitochondrial ARTS protein promotes apoptosis through targeting XIAPCaspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaksDirect DNA binding by Brca1Complex formation by the human RAD51C and XRCC3 recombination repair proteinsBMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repairEndogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer
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P2860
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
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artículu científicu
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scholarly article
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wetenschappelijk artikel
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A critical role for histone H2 ...... nuclear foci after DNA damage
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A critical role for histone H2 ...... nuclear foci after DNA damage
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A critical role for histone H2 ...... nuclear foci after DNA damage
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A critical role for histone H2 ...... nuclear foci after DNA damage
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A critical role for histone H2 ...... nuclear foci after DNA damage
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A critical role for histone H2 ...... nuclear foci after DNA damage
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A critical role for histone H2 ...... nuclear foci after DNA damage
@ast
A critical role for histone H2 ...... nuclear foci after DNA damage
@en
A critical role for histone H2 ...... nuclear foci after DNA damage
@nl
P2093
P3181
P1433
P1476
A critical role for histone H2 ...... nuclear foci after DNA damage
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P2093
C U Kirchgessner
E P Rogakou
V Yamazaki
W M Bonner
P304
P3181
P356
10.1016/S0960-9822(00)00610-2