Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
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Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTppLarge extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutationsUnderstanding phenotypic variation in rodent models with germline Apc mutationsTransgenic and gene knockout mice in gastric cancer researchAxin cancer mutants form nanoaggregates to rewire the Wnt signaling networkTime, space, and disorder in the expanding proteome universe.The intrinsic disorder alphabet. III. Dual personality of serine.A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutantWnt and BMP Signaling Crosstalk in Regulating Dental Stem Cells: Implications in Dental Tissue Engineering.Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction.IWP2 impairs the development of porcine somatic cell nuclear transfer embryos via Wnt signaling pathway inactivation.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesTumour cell invasion: an emerging role for basal epithelial cell extrusion.Molecular, phenotypic aspects and therapeutic horizons of rare genetic bone disorders.Dynamic multiprotein assemblies shape the spatial structure of cell signalingSingle nucleotide variations: biological impact and theoretical interpretation.Genetic analysis of colon tumors induced by a dietary carcinogen PhIP in CYP1A humanized mice: Identification of mutation of β-catenin/Ctnnb1 as the driver gene for the carcinogenesis.Presence of c.3956delC mutation in familial adenomatous polyposis patients from Brazil.Bicodon bias can determine the role of synonymous SNPs in human diseases.The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling.Mitotic spindle (DIS)orientation and DISease: cause or consequence?MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway.Combined sequence and sequence-structure based methods for analyzing FGF23, CYP24A1 and VDR genes.More than two decades of Apc modeling in rodentsInhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a.On the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseasesExpression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer.Therapeutic targets associated to E-cadherin dysfunction in gastric cancer.Current and future intratumoral targeted treatment for pancreatic cancer.Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).Designing disorder: Tales of the unexpected tails.APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly.Prognostic significance of WNT and hedgehog pathway activation markers in cancer of unknown primary.The CRM1 nuclear export protein in normal development and disease.The destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma.Characterizing genomic alterations in cancer by complementary functional associations.The prognostic significance of APC gene mutation and miR-21 expression in advanced-stage colorectal cancer.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.Wnt/β‑catenin pathway activation and silencing of the APC gene in HPV‑positive human cervical cancer‑derived cells.Scutellaria barbata D. Don inhibits colorectal cancer growth via suppression of Wnt/β-catenin signaling pathway.
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Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@ast
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@en
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@en-gb
Messing up disorder: how do mi ...... or protein APC lead to cancer?
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type
label
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@ast
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@en
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@en-gb
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@nl
prefLabel
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@ast
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@en
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@en-gb
Messing up disorder: how do mi ...... or protein APC lead to cancer?
@nl
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Messing up disorder: how do mi ...... or protein APC lead to cancer?
@en
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Zeinab Anvarian
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10.1186/1476-4598-10-101
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2011-08-22T00:00:00Z
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P6179
1047879719