Structural basis of the Axin-adenomatous polyposis coli interaction - Test2 - elhamkhani - TriplyDB

Structural basis of the Axin-adenomatous polyposis coli interaction

Structural basis of the Axin-adenomatous polyposis coli interaction

http://www.wikidata.org/entity/Q24594194

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Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein The Wnt-dependent signaling pathways as target in oncology drug discovery Wnt signaling: the good and the bad The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells Toggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexes Animal models of colorectal cancer Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network beta-catenin destruction complex: insights and questions from a structural perspective The β-catenin destruction complex Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions Bladder cancer initiating cells (BCICs) are among EMA-CD44v6+ subset: novel methods for isolating undetermined cancer stem (initiating) cells.Post genome-wide association studies functional characterization of prostate cancer risk loci.Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system.The evolutionary origin of epithelial cell-cell adhesion mechanisms Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases.Wnt signaling in disease and in development.Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation Characterization of the GRK2 binding site of Galphaq.Intrinsic disorder in scaffold proteins: getting more from less The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled Effects of aging and anatomic location on gene expression in human retina.G-protein signaling: back to the future Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex.Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and molecular dynamics simulations.The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling.

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P2860

Structural basis of the Axin-adenomatous polyposis coli interaction

http://www.wikidata.org/entity/Q24594194

description

2000 nî lūn-bûn

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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2000 թվականի մայիսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Structural basis of the Axin-adenomatous polyposis coli interaction

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Structural basis of the Axin-adenomatous polyposis coli interaction

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Structural basis of the Axin-adenomatous polyposis coli interaction

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Structural basis of the Axin-adenomatous polyposis coli interaction

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Structural basis of the Axin-adenomatous polyposis coli interaction

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Structural basis of the Axin-adenomatous polyposis coli interaction

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Structural basis of the Axin-adenomatous polyposis coli interaction

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The EMBO Journal

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Structural basis of the Axin-adenomatous polyposis coli interaction

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K E Spink

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P Polakis

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P2860

Identification of c-MYC as a target of the APC pathway

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Signal transduction by the Wnt family of ligands

WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Improved methods for building protein models in electron density maps and the location of errors in these models

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4511730

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10811618

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384355

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