Kinesin-5: cross-bridging mechanism to targeted clinical therapy
about
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapyKinesin-5 allosteric inhibitors uncouple the dynamics of nucleotide, microtubule, and neck-linker binding sites.Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors.Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells.Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data.OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancerSpontaneous Formation of a Globally Connected Contractile Network in a Microtubule-Motor System.Chaperonin-Dendrimer Conjugates for siRNA Delivery.Observation of significant biomarkers in osteosarcoma via integrating module- identification method with attract.Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase.First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors.KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics.Death receptor 6 promotes ovarian cancer cell migration through KIF11
P2860
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P2860
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@ast
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@en
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@en-gb
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@nl
type
label
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@ast
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@en
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@en-gb
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@nl
prefLabel
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@ast
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@en
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@en-gb
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@nl
P2093
P2860
P3181
P1433
P1476
Kinesin-5: cross-bridging mechanism to targeted clinical therapy
@en
P2093
Edward J Wojcik
Jessica Richard
Liqiong Liu
Rebecca S Buckley
Sunyoung Kim
Thomas M Huckaba
P2860
P304
P3181
P356
10.1016/J.GENE.2013.08.004
P407
P577
2013-12-01T00:00:00Z