ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
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Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming abilityThe cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patientsNijmegen breakage syndrome (NBS)Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASPHuman single-stranded DNA binding proteins are essential for maintaining genomic stabilityMelatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathwaysMicroRNAs in the DNA Damage/Repair Network and CancerKinesin-5: cross-bridging mechanism to targeted clinical therapyHERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomesThe Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genesRegulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphataseA genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stabilityThe yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resectionThe splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesionA PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombinationATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expressionE3 ligase RFWD3 participates in replication checkpoint controlRFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damageRNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyDNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilizationA WD-repeat protein stabilizes ORC binding to chromatinRequirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cellsAPRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancerPI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activityATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repairMolecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membraneA genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stabilityA DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signalingSUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damageRAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationPRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryIdentification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapyTyrosine dephosphorylation of H2AX modulates apoptosis and survival decisionsDrosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombinationMammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
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P2860
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
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2007年の論文
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2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年學術文章
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name
ATM and ATR substrate analysis ...... works responsive to DNA damage
@ast
ATM and ATR substrate analysis ...... works responsive to DNA damage
@en
ATM and ATR substrate analysis ...... works responsive to DNA damage
@en-gb
ATM and ATR substrate analysis ...... works responsive to DNA damage
@nl
type
label
ATM and ATR substrate analysis ...... works responsive to DNA damage
@ast
ATM and ATR substrate analysis ...... works responsive to DNA damage
@en
ATM and ATR substrate analysis ...... works responsive to DNA damage
@en-gb
ATM and ATR substrate analysis ...... works responsive to DNA damage
@nl
prefLabel
ATM and ATR substrate analysis ...... works responsive to DNA damage
@ast
ATM and ATR substrate analysis ...... works responsive to DNA damage
@en
ATM and ATR substrate analysis ...... works responsive to DNA damage
@en-gb
ATM and ATR substrate analysis ...... works responsive to DNA damage
@nl
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ATM and ATR substrate analysis ...... works responsive to DNA damage
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Bryan A Ballif
E Robert McDonald
Kristen E Hurov
Nicole Solimini
Yaniv Lerenthal
Yosef Shiloh
Zhenming Zhao
P304
P3181
P356
10.1126/SCIENCE.1140321
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P577
2007-05-25T00:00:00Z