about
P688
The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfateThe putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfateAutism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfateHeparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfationSynovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spineDisruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient miceMammalian brain morphogenesis and midline axon guidance require heparan sulfateEndothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodesHeparan sulfate is required for embryonic stem cells to exit from self-renewalUnsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells.Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling.Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells.Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo.Toward an understanding of the short bone phenotype associated with multiple osteochondromas.Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homingPerichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development.Aberrant perichondrial BMP signaling mediates multiple osteochondromagenesis in miceMutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix.Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones.Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.Signaling systems affecting the severity of multiple osteochondromas.Multiple roles of epithelial heparan sulfate in stomach morphogenesis.Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuriaAbnormal sodium and water homeostasis in mice with defective heparan sulfate polymerization
P921
Q22011093-544CD4F4-F6C3-4600-B6B0-2D9F8A68DBDEQ24323532-13966993-F78A-463D-8BF6-4D99ECEA0583Q24598684-4D940FA4-3E70-4732-9706-CEC85C685F76Q28115828-92A3B998-926C-407F-8DCF-EB2AFA2FAF13Q28507176-D6F4F978-46FE-4B00-9382-5E40F8469F18Q28586958-C7FB7261-E6FE-4FBF-AB73-61F6B73DCC4CQ28588474-BDA77DD1-58F4-4F85-BBDE-B63BDE374087Q30497539-9AFD554A-58A1-403D-B87B-F535D8403141Q33648580-500220CC-775E-4978-A6C9-908933A9E513Q33658041-F3EC594F-7304-4D27-B906-D220D9C3F238Q33719846-9FD926EB-A7A7-4962-AB37-A4FB8CEBB821Q33911298-F84D690B-BEC2-4CC0-88DF-0A7F3220F42DQ35221235-8D286D94-A3A6-44E7-90DA-0E35392EDC6AQ35608791-38C6D75A-3854-4731-BD81-76CC29343D85Q35752233-3FCB3A81-2B41-4882-B48E-AE1C3BA57344Q36080282-2FF9E0A9-042E-4B08-9411-55207CB24F61Q36433979-9F4D21F9-1B32-4E73-92C1-4920102DFD6CQ36933108-E25EA1BB-CEC0-4BF8-8E57-49C2F2D7BE1EQ36960975-3F5127FA-C7F0-42EF-AC93-59721554A729Q37069124-5A7C6248-BEE2-46B9-B386-D81733C3ED8FQ41139571-B00E8CF6-F772-4922-BB64-AB5250F6F432Q41252283-01B4596F-9743-418B-9557-9BC23D2193F1Q41808585-B6BBFAAA-5821-4022-BAAD-C0196BA8318BQ42133421-C4DF678A-3492-46B1-B742-EC3C19861927Q42691865-478DD3D2-8981-4260-BA52-CCF8AA74DE0BQ47397369-A86C0E29-9CCF-462F-9F3E-993F2883F935Q47432428-B5B3BB2F-6834-4FD5-944D-3894DFD337C9Q51739622-A3258D31-6E5D-4661-A674-A1D5C323076BQ52560268-83D3EC40-FB80-4488-964F-C5725C24750FQ81279178-6E054AFB-4EA2-4565-AC61-366F6897D222Q92312023-44C90145-2879-4C6A-ADA2-6607BF7E4EEE
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Exostoses (multiple) 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Exostoses
@nl
Exostosin glycosyltransferase 1
@en
type
label
Exostoses
@nl
Exostosin glycosyltransferase 1
@en
altLabel
Ext1
@en
exostoses (multiple) 1
@en
exostosin-1
@en
glucuronosyl-N-acetylglucosami ...... -acetylglucosaminyltransferase
@en
multiple exostoses protein 1 homolog
@en
prefLabel
Exostoses
@nl
Exostosin glycosyltransferase 1
@en