Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.
about
Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromasIsolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiationIndian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levelsGlycan Engineering for Cell and Developmental BiologyShort and tall stature: a new paradigm emergesPathophysiology of heparan sulphate: many diseases, few drugsRole of E-cadherin and other cell adhesion molecules in survival and differentiation of human pluripotent stem cellsExtracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesisHuman genetic disorders and knockout mice deficient in glycosaminoglycanHeparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostosesSynovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spineJAWS coordinates chondrogenesis and synovial joint positioningRedundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal developmentMice deficient in Ext2 lack heparan sulfate and develop exostosesPresphenoidal synchondrosis fusion in DBA/2J mice.Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytesRegulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher.delta-EF1 is a negative regulator of Ihh in the developing growth plate.Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family.Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.EXTra hit for mouse osteochondroma.Multiple osteochondromas: clinicopathological and genetic spectrum and suggestions for clinical management.The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering ApplicationsConditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton.Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling.Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturationHSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas.Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma.Clinical implications of hedgehog signaling pathway inhibitorsTransglutaminase 2 regulates early chondrogenesis and glycosaminoglycan synthesis.Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidaseSite-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal micePlanar cell polarity signaling in craniofacial development.Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation.Novel Genetic Loci Control Calcium Absorption and Femur Bone Mass as Well as Their Response to Low Calcium Intake in Male BXD Recombinant Inbred MiceGrowth of limb muscle is dependent on skeletal-derived Indian hedgehog.Solute transport in growth plate cartilage: in vitro and in vivo.When sugars guide axons: insights from heparan sulphate proteoglycan mutants.
P2860
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P2860
Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Ext1-dependent heparan sulfate ...... ing endochondral ossification.
@en
Ext1-dependent heparan sulfate ...... ing endochondral ossification.
@nl
type
label
Ext1-dependent heparan sulfate ...... ing endochondral ossification.
@en
Ext1-dependent heparan sulfate ...... ing endochondral ossification.
@nl
prefLabel
Ext1-dependent heparan sulfate ...... ing endochondral ossification.
@en
Ext1-dependent heparan sulfate ...... ing endochondral ossification.
@nl
P2093
P1433
P1476
Ext1-dependent heparan sulfate ...... ing endochondral ossification.
@en
P2093
Andrea Vortkamp
Lydia Koziel
Melanie Kunath
Olivia G Kelly
P304
P356
10.1016/J.DEVCEL.2004.05.009
P407
P577
2004-06-01T00:00:00Z