about
P688
Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cellsCsx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heartFoxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanismsMissense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesisGATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5miR-145 and miR-143 regulate smooth muscle cell fate and plasticityNKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytesRecruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcriptionCongenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 moduleThe transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylasesNkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart blockCSX/Nkx2.5 modulates differentiation of skeletal myoblasts and promotes differentiation into neuronal cells in vitroJumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factorsCooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formationAn Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factorsHop is an unusual homeobox gene that modulates cardiac developmentMolecular pathway for the localized formation of the sinoatrial nodeCooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heartComplex SUMO-1 regulation of cardiac transcription factor Nkx2-5UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic developmentThe cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elementsGATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesisMurine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptationDifferential expression and function of Tbx5 and Tbx20 in cardiac developmentSlow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiationCardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heartFoxh1 is essential for development of the anterior heart fieldTinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across speciesNkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction systemA molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system developmentTbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart fieldThe cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAsThe combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formationCharacterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoproteinHistone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesisCsm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heartCooperative interaction of Nkx2.5 and Mef2c transcription factors during heart developmentMyocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis
P921
Q22008552-4598E41A-4AA8-4A9A-A423-CCD0687A1CB0Q24292433-0F3A5929-DA22-4F56-958F-D5923C405B67Q24296379-ADC51268-43A4-46DB-80F9-943AC7CE697AQ24301402-930B2F1F-62E5-4D93-8F31-2DEEA23CB78EQ24307366-58201EDF-67A4-4A05-9B32-D47ECB5FE434Q24311186-6EE12C22-480F-4CB2-88A4-313B421CB464Q24315020-CBCE91EE-6AB0-457E-9A6D-D86443430FF3Q24315851-2F23A529-BBEA-4428-9AF0-1909E9052F7FQ24318764-E7360E3C-D183-4122-A447-71805BC8AC8FQ24328902-4BF3B4A9-8E2B-4BE2-A343-5EF74F016662Q24338156-54DC1A6A-EB9D-4F32-A287-9C749E290C8FQ24338240-1416AB8A-6461-4074-A038-50729368AF21Q24559996-8D06C183-4F01-4076-80CE-0BACEC2332CAQ24675337-DF6DF265-2F9C-416A-B77A-14501BC5806FQ27863351-3D5DE021-621F-47C2-BC6B-1F2583A8D549Q28118264-CBFEE2ED-80DA-402C-9742-8185D9BC2113Q28203645-5FBF5C7A-847F-4DAA-BA81-D761699E969CQ28284039-7078CCE8-C57C-4845-8E43-35514E584237Q28289031-B54C8CB6-1A7B-4B08-B22A-2485D9D9D2E2Q28477049-784C49F3-0A10-4451-A2BB-F4655CDE9795Q28484095-63FA6FDC-2C09-4B43-AC0B-77D447CDB94EQ28504813-47ED39EF-EFCF-420B-B190-0A808976155EQ28506308-360117FF-937B-4613-8D43-6EADEB6F7CABQ28506898-3D97D7A3-B957-4F35-86C7-A63FDB4E7B20Q28507763-C8E28181-E238-4EAB-B7D6-4DF4AFF4FB48Q28508533-150D103D-BC11-430B-AE7B-0D6D3A690679Q28508704-486B1363-C1F6-46B8-9B41-2E4272BCE05EQ28510052-E183409B-EEA8-409D-9796-387CB8AEE5CCQ28511957-090DAAC0-FF9C-42DC-9A48-14E29A466BB2Q28511985-5F46FE58-176B-45A8-B423-4503A84DF9F5Q28512124-760E5DC0-43F5-40DF-8445-2428A55713F4Q28512323-B1B47CE3-24BE-4DEE-8915-849D488ADFE7Q28512364-B04034B5-18CB-40F1-8668-D74D02FD077EQ28512635-41AAEA35-FE64-4900-BCB7-A2C714D6A7A8Q28513199-C92E19FA-9F58-49E4-B4D7-BCF62BA9709CQ28578096-950E33B2-6527-443F-9922-8465777A1883Q28585453-09B50164-7B0B-49E4-BB3F-E1D5A62628D1Q28587235-D895120D-44AA-4EFE-ABA2-B3EF0E9F1208Q28587943-7D816B27-66CB-4340-9F2F-3BC00F7D5A4CQ28587987-188DD5BD-0B92-4E69-B132-AB0DD76130E0
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in NK2 homeobox 5
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
NK2 homeobox 5
@en
type
label
NK2 homeobox 5
@en
altLabel
Drosophila NK2 transcription factor related, locus 5
@en
NK2 transcription factor related, locus 5
@en
Nkx2-5
@en
cardiac-specific homeobox
@en
homeobox protein CSX
@en
homeobox protein NK-2 homolog E
@en
homeobox protein Nkx-2.5
@en
prefLabel
NK2 homeobox 5
@en
P527
P680
P681
P682
P352
P638
P279
P31
P352
P637
XP_006523860
P680
P681
P682
P702
P703
P705
ENSMUSP00000015723
ENSMUSP00000157537