about
P688
Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesisOverexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterationsThe nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathwayNotch signaling is essential for ventricular chamber developmentSegmental expression of Notch and Hairy genes in nephrogenesisIntegration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.Mutations in NOTCH1 cause aortic valve diseaseRITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factorMYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptorInteraction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathwaysBinding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2Notch signaling controls multiple steps of pancreatic differentiationA regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domainMouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methodsHes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signallingPhysical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)Inhibitory role of Notch1 in calcific aortic valve diseaseCombined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transitionHes1 and Hes5 as notch effectors in mammalian neuronal differentiation.Notch1 represses osteogenic pathways in aortic valve cellsThe Mesp2 transcription factor establishes segmental borders by suppressing Notch activityArtery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesisCanonical notch signaling functions as a commitment switch in the epidermal lineageDirect regulation of intestinal fate by NotchHey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of CortiNotch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathwayRBP-L, a transcription factor related to RBP-JkappaFringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1Essential role of endothelial Notch1 in angiogenesisCross-regulation between Notch and p63 in keratinocyte commitment to differentiationNotch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb budOscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factorsFibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitorsRBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cellsJag2-Notch1 signaling regulates oral epithelial differentiation and palate developmentSegmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant miceNotch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis
P921
Q24292921-57DFB925-96CD-4FA3-948E-E551700AEB5BQ24298328-D8594699-0B5F-4B08-885D-85869416BECAQ24298994-72D0A737-2716-41D9-9DF7-14F20B6147BFQ24299001-386CC54F-F145-49C6-9DA1-BEA32B077E0AQ24299797-DBE6DB2A-243B-4038-9F66-C8EB1E643C35Q24301606-89B8594C-7347-4AF2-81C6-F1BF6E44BDB2Q24307999-3CD11B9E-F319-4DC5-AF60-7B29BE0CA3DDQ24308025-FC5BA74E-BA5D-48AF-A43E-C665BC31E14FQ24311481-8D547E2E-BCB9-4219-AA01-AEC8E115D57DQ24315135-53159790-61A6-434D-B1D1-D9416B934723Q24315801-6ECA4D3E-A9C0-4512-8CBB-CCA011A19AA1Q24317627-619C1A5C-C6B8-4DC3-A245-B528984C1568Q24550771-3D82EFD9-7BA8-4DDA-B7B4-30FC92D350B2Q24569636-D9C307EB-A937-4ECD-8AA6-DB6DD403628EQ27863408-3D0CA447-5574-4D56-AB45-03F7B2D2FE1FQ28141707-AEDDEADF-3FE0-4668-A6AC-4CA74D4FE829Q28146235-87CF34BD-7BCC-4FFD-8CFD-4631A7356FABQ28262816-A3E91451-7956-4EF8-A0DD-50C3B5C5CB25Q28286560-DE3F9FC5-EF7B-4021-8BB5-65C0878971CBQ28478035-07497E2D-9F10-4E79-8FA5-BBC1875577E4Q28505095-1A64CA1D-F654-475F-81E2-EB1F7FCE974DQ28505355-2B12353E-A938-499D-891F-DE6C9D8AC3F4Q28505877-A99E18EB-BEAE-4317-86D6-FA106B7A0C18Q28505901-EB1B9A6A-ACB7-4F47-AF49-4CEE6B76922AQ28506090-4349E3AA-398C-408B-8406-CC1059FABD82Q28506621-944F9582-618F-46D2-8B21-5D53B40FB5A9Q28507015-707F2AE8-D4A7-4765-B708-7D4B0D32C2FBQ28507372-E11147EE-3273-488F-B7D1-119BF405F91BQ28507459-A0A4B4AE-B120-4330-BEDE-E5F59B82ED36Q28508784-D604DFB4-7AEF-4853-A350-72E5228D2977Q28509366-BD89D629-424E-4B41-9959-83048A677E33Q28509482-21F7059E-679F-41BB-8CF8-641EFFECB945Q28510156-25EC0CCA-85D8-4368-8DCB-839010588C8CQ28510500-9701EA59-25B7-4B6A-9119-843AEBD62551Q28510928-23890DDA-0AC6-4F5C-8A55-C9D65DCBAE48Q28511435-E204F677-147C-4204-8963-237CED1925BCQ28511728-315521C3-4196-447C-8A63-C8D1AC26B3E8Q28512267-81CFFA23-6AB6-46F9-98CD-10DC40621D0CQ28512351-8242C839-84C5-44F4-B07D-C1251FC0E63CQ28512806-9FE00B33-5312-427D-8697-035EC97C09E9
P921
description
Säugetierprotein
@de
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Notch 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Notch 1
@en
Notch 1
@nl
type
label
Notch 1
@en
Notch 1
@nl
altLabel
Motch A
@en
Notch gene homolog 1
@en
Notch1
@en
mT14
@en
major type A protein
@en
neurogenic locus notch homolog protein 1
@en
p300
@en
transmembrane receptor Notch1
@en
prefLabel
Notch 1
@en
Notch 1
@nl
P361
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P638
P680
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P352
P637
P31
P352
P361
P527
P637
P638
P680
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P702
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P705
ENSMUSP00000028288
ENSMUSP00000115258