Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
about
Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alphaReciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CARThe xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARPhenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B geneAlternatively spliced isoforms of the human constitutive androstane receptorDiurnal difference in CAR mRNA expressionComplex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CARAlternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorHighly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).Detection of designer steroidsRegulation of the cytosolic sulfotransferases by nuclear receptorsModulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR for metabolic diseasesRole of Nuclear Receptors in Central Nervous System Development and Associated DiseasesA brief history of the discovery of PXR and CAR as xenobiotic receptorsThe repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 geneActivation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional stateIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesInhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivatorsDehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptorXenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR betaOrphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligandsRecruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactionsInvestigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expressionTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationInduction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liverEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsNovel functions of PXR in cardiometabolic disease.Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).Nuclear receptors: the evolution of diversity.Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.Phenobarbital Meets Phosphorylation of Nuclear ReceptorsTissue-specific chromatin structure of the phenobarbital-responsive unit and proximal promoter of CYP2B1/2 and modulation by phenobarbital.Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Activation of xenobiotic receptors: driving into the nucleus.Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).Steroid hormone receptors: evolution, ligands, and molecular basis of biologic function.
P2860
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P2860
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@ast
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@en
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@en-gb
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@nl
type
label
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@ast
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@en
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@en-gb
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@nl
prefLabel
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@ast
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@en
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@en-gb
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@nl
P2093
P3181
P356
P1433
P1476
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
@en
P2093
B M Forman
P2888
P304
P3181
P356
10.1038/26996
P407
P577
1998-10-01T00:00:00Z
P6179
1040686826