Targeting xenobiotic receptors PXR and CAR for metabolic diseases - Test2 - elhamkhani - TriplyDB

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

http://www.wikidata.org/entity/Q27011149

about

Modulation of xenobiotic receptors by steroids Targeting xenobiotic receptors PXR and CAR in human diseases Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells Impact of nutrient excess and endothelial nitric oxide synthase on the plasma metabolite profile in mice.Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells A Diet-Sensitive BAF60a-Mediated Pathway Links Hepatic Bile Acid Metabolism to Cholesterol Absorption and Atherosclerosis Perturbations in polar lipids, starvation survival and reproduction following exposure to unsaturated fatty acids or environmental toxicants in Daphnia magna.Molecular Interactions between NAFLD and Xenobiotic Metabolism.Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice.Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.Pregnane X Receptor and Cancer: Context-Specificity is Key.Nuclear receptors in bile acid metabolism Epigenetic regulation of pregnane X receptor activity.Bile acid receptors as targets for drug development.Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery.Nuclear hormone receptors PXR and CAR and metabolic diseases.Metabolic syndrome and the environmental pollutants from mitochondrial perspectives.MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks.Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion.Activation of the Constitutive Androstane Receptor by Monophthalates Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor.Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.Activation of constitutive androstane receptor ameliorates renal ischemia-reperfusion induced liver and kidney injury.An intracrine view of sex steroids, immunity, and metabolic regulation.In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets

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P2860

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012年の論文

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Trends in Pharmacological Sciences

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

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Jie Gao

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Wen Xie

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High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

Mechanisms for insulin resistance: common threads and missing links

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

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