Targeting xenobiotic receptors PXR and CAR for metabolic diseases
about
Modulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR in human diseasesImproved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiomePregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationSystems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse OutcomesIrisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cellsImpact of nutrient excess and endothelial nitric oxide synthase on the plasma metabolite profile in mice.Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cellsA Diet-Sensitive BAF60a-Mediated Pathway Links Hepatic Bile Acid Metabolism to Cholesterol Absorption and AtherosclerosisPerturbations in polar lipids, starvation survival and reproduction following exposure to unsaturated fatty acids or environmental toxicants in Daphnia magna.Molecular Interactions between NAFLD and Xenobiotic Metabolism.Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice.Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.Pregnane X Receptor and Cancer: Context-Specificity is Key.Nuclear receptors in bile acid metabolismEpigenetic regulation of pregnane X receptor activity.Bile acid receptors as targets for drug development.Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery.Nuclear hormone receptors PXR and CAR and metabolic diseases.Metabolic syndrome and the environmental pollutants from mitochondrial perspectives.MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks.Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion.Activation of the Constitutive Androstane Receptor by MonophthalatesIntegration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor.Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.Activation of constitutive androstane receptor ameliorates renal ischemia-reperfusion induced liver and kidney injury.An intracrine view of sex steroids, immunity, and metabolic regulation.In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets
P2860
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P2860
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@ast
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@en
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@nl
type
label
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@ast
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@en
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@nl
prefLabel
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@ast
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@en
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@nl
P2860
P3181
P1476
Targeting xenobiotic receptors PXR and CAR for metabolic diseases
@en
P2860
P3181
P356
10.1016/J.TIPS.2012.07.003
P407
P577
2012-10-01T00:00:00Z