Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
about
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's diseaseTransthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?beta-Amyloid degradation and Alzheimer's diseaseCardiovascular Risk Factors for Alzheimer's DiseaseAmyloid-associated depression: a prodromal depression of Alzheimer disease?Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondriaMyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's diseaseA capillary electrophoresis method for evaluation of Abeta proteolysis in vitroZinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluidApoE promotes the proteolytic degradation of AbetaValsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer diseaseInsulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoReduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleRole of ROS and RNS Sources in Physiological and Pathological ConditionsDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsInflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's DiseaseAlzheimer's Disease: Mechanism and Approach to Cell TherapyClearance systems in the brain-implications for Alzheimer diseaseInsulin in the brain: there and back againAlzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactionsProteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson diseaseGeneral anesthetics and β-amyloid proteinAberrant insulin signaling in Alzheimer's disease: current knowledgeTransnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice.Identification of the allosteric regulatory site of insulysinYeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme.Current and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysAlzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzymeDecreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease familiesStatins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretionInvolvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposureSmall-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screeningNeprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesInsulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)Mutation of active site residues of insulin-degrading enzyme alters allosteric interactionsThe catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesisModulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stressMechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's diseaseA humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice
P2860
Q21136406-98C54387-DB05-4EA1-A3FD-313DA1B85DC7Q21202832-290D4FF7-220D-48E2-BBFE-2464548569ACQ21284467-F31F5314-CC77-4D31-AA63-962506FFCBA9Q22242643-AFEA49EB-E9EB-477C-ADDA-C95DE625BE56Q22253023-495F7708-E9CE-42C0-8824-8B364365AC09Q24300365-4C2A6F9E-B200-47CC-86FA-B23F9763CB30Q24616286-D94631B0-1C3B-40AC-9DFB-D3183003AB8AQ24620093-9B58F061-E645-4C47-BE54-DF6416578EB7Q24649556-B7B2EB9A-6C42-4574-B722-F869D5B33F15Q24651102-0EC8001B-29E6-49DD-98DA-D0DE6F1CAEAEQ24675823-E9ABB1E9-5A99-4A3B-8D69-A0D1FE94EFECQ24683214-D89F2C47-FAA2-4BFF-992C-D0A79D9A315BQ24684471-0C4D5E0B-C910-4629-BA6F-A294D474FF27Q26740342-89F05C04-A62B-4BF9-9B5A-BADF2B9261D8Q26750648-F4654B3D-F107-4482-8826-A7AF6064D864Q26773657-3592F3CC-D2B7-49B5-967D-5F2560293593Q26778149-DA0DBB1A-64E2-4DC3-AAE4-955C7F518415Q26801541-F92B03AF-F26C-4105-BF6C-29DDC6279A65Q26825385-5B0F4709-7C41-4BFC-91B9-9FB15C8A1727Q26864965-10512D84-AF79-4BE1-81FF-8DC84F89F9B9Q27005843-414C15A0-444F-4D99-BA27-DAE2124F0E04Q27010208-5929AC5F-1DAE-4F8E-90B7-F94260559370Q27024222-98702549-97EF-40C3-9FFB-C0657C153356Q27315991-471F7460-3182-47E7-9FBB-7C3C08D35F0FQ27335211-B1A57EE2-F0B3-4D59-90AC-EDBAA90694E8Q27931965-3C417B7F-FFFC-41B9-B7CA-50075DD3790DQ27932546-59BAEDF0-14FD-4356-937E-FC474B1EDE9BQ28081678-445EB2A0-5E69-43F3-AFD1-E3D64A2FE796Q28216644-293C4439-C49B-4834-86BA-F0E5CFAE810DQ28284636-5244313A-4B5A-46F1-BD9D-E2E1494F907CQ28294279-2C9F6ED0-6DE3-4077-BF88-3BA550A7A1CAQ28391254-637A4E41-153A-4B5D-8D1B-EE033160664AQ28475342-7591E6C5-9991-488E-AA50-85ED8658FD05Q28505860-2A3A89E7-AFC3-4423-B7A6-614EFFF5665DQ28568146-47642476-20D4-4104-8637-B97E87B7443AQ28570444-B0DA0D6E-7677-4D3F-942F-F742B1D8C84BQ28574836-D9A7537C-67B4-4553-85B3-96BCC3115959Q28576650-53B0E8ED-5262-4AFB-809B-BCD3D4874F55Q28731520-CFEF409D-C673-4BF9-A3CC-E1BCB17372FDQ28743487-489CC66B-4D95-4E42-B16F-BC8F8E0B673F
P2860
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@ast
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@en
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@en-gb
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@nl
type
label
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@ast
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@en
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@en-gb
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@nl
prefLabel
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@ast
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@en
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@en-gb
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@nl
P2093
P921
P3181
P356
P1476
Insulin-degrading enzyme regul ...... id beta-protein by degradation
@en
P2093
D J Selkoe
K Vekrellis
M B Podlisny
M R Rosner
P304
P3181
P356
10.1074/JBC.273.49.32730
P407
P577
1998-12-04T00:00:00Z