Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)
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A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2bInsulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoReduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleEnhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading EnzymeYeast as a tractable genetic system for functional studies of the insulin-degrading enzyme.Synaptic and endosomal localization of active gamma-secretase in rat brain.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesMarginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats.Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's preventionProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brainAnalysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model.Evidence for defective retinoid transport and function in late onset Alzheimer's diseaseCalcium dyshomeostasis and intracellular signalling in Alzheimer's disease.Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivoSorting nexin 27 regulates Aβ production through modulating γ-secretase activity.Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)Does diabetes protect or provoke Alzheimer's disease? Insights into the pathobiology and future treatment of Alzheimer's disease.Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolismCatalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in miceAmyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis.Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function -- role of glucose metabolism and insulin signalling.Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.Role of insulin metabolism disturbances in the development of Alzheimer disease: mini review.Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretaseIntramembrane proteolysis by gamma-secretase.Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults.Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's DiseaseNuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity.A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.Association of type 2 diabetes with brain atrophy and cognitive impairment.The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases.γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?
P2860
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P2860
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)
description
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im April 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/04/19)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/04/19)
@nl
наукова стаття, опублікована у квітні 2002
@uk
name
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@ast
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@en
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@nl
type
label
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@ast
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@en
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@nl
prefLabel
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@ast
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@en
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@nl
P2093
P2860
P3181
P356
P1476
Insulin-degrading enzyme rapid ...... in intracellular domain (AICD)
@en
P2093
Harald Steiner
Michael Willem
Sven Lammich
P2860
P304
13389–13393
P3181
P356
10.1074/JBC.M111571200
P407
P577
2002-04-19T00:00:00Z