Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes
about
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.Nuclear structure in normal and Bloom syndrome cellsReplication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activityPotent inhibition of werner and bloom helicases by DNA minor groove binding drugsCharacterization of the human and mouse WRN 3'-->5' exonucleaseRegulation and localization of the Bloom syndrome protein in response to DNA damageHuman RECQL5 participates in the removal of endogenous DNA damageWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkTelomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesRecql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1The RecQ DNA helicases in DNA repairHuman RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyThe Bloom's syndrome gene product promotes branch migration of holliday junctionsThe C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stabilityThe role of RecQ helicases in non-homologous end-joiningRECQL4 in genomic instability and agingRole of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae.Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicaseCancer predisposition caused by elevated mitotic recombination in Bloom miceA novel protein interacts with the Werner's syndrome gene product physically and functionallySubstrate-specific inhibition of RecQ helicaseCovalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase.Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development.Unwinding protein complexes in ALTernative telomere maintenance.Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA)Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.dRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila.The involvement of human RECQL4 in DNA double-strand break repair.WRN helicase expression in Werner syndrome cell linesSelective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.Formation of complex and unstable chromosomal translocations in yeastWerner syndrome exonuclease catalyzes structure-dependent degradation of DNA.Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.Functional interaction between the Werner Syndrome protein and DNA polymerase deltaDifferential regulation of human RecQ family helicases in cell transformation and cell cycle.Biochemical characterization of the small isoform of Drosophila melanogaster RECQ5 helicase.
P2860
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P2860
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Cloning of two new human helic ...... e species in higher eukaryotes
@ast
Cloning of two new human helic ...... e species in higher eukaryotes
@en
Cloning of two new human helic ...... e species in higher eukaryotes
@en-gb
Cloning of two new human helic ...... e species in higher eukaryotes
@nl
type
label
Cloning of two new human helic ...... e species in higher eukaryotes
@ast
Cloning of two new human helic ...... e species in higher eukaryotes
@en
Cloning of two new human helic ...... e species in higher eukaryotes
@en-gb
Cloning of two new human helic ...... e species in higher eukaryotes
@nl
prefLabel
Cloning of two new human helic ...... e species in higher eukaryotes
@ast
Cloning of two new human helic ...... e species in higher eukaryotes
@en
Cloning of two new human helic ...... e species in higher eukaryotes
@en-gb
Cloning of two new human helic ...... e species in higher eukaryotes
@nl
P2093
P356
P1433
P1476
Cloning of two new human helic ...... e species in higher eukaryotes
@en
P2093
P304
P356
10.1006/GENO.1998.5595
P407
P577
1998-12-15T00:00:00Z