Cancer predisposition caused by elevated mitotic recombination in Bloom mice
about
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repairBLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairUbiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombinationFBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51BRCTx is a novel, highly conserved RAD18-interacting proteinFBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cellsRecql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.Homologous recombination: from model organisms to human disease.MPS1-dependent mitotic BLM phosphorylation is important for chromosome stabilityThe RecQ DNA helicases in DNA repairTransposon-mediated genome manipulation in vertebratesEme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cellsRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingEndogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancerA multiprotein nuclear complex connects Fanconi anemia and Bloom syndromeManipulating mitotic recombination in the zebrafish embryo through RecQ helicasesRECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filamentsThe C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stabilityNon-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerConnecting the Dots: From DNA Damage and Repair to AgingModeling the study of DNA damage responses in miceMechanism of RecO recruitment to DNA by single-stranded DNA binding proteinThe genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discoveryRAD51 mutants cause replication defects and chromosomal instabilityMechanisms and consequences of somatic mosaicism in humansInsertional mutagenesis in mice: new perspectives and toolsTelomere shortening exposes functions for the mouse Werner and Bloom syndrome genesLoss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppressionRECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathwayMutation of the murine Bloom's syndrome gene produces global genome destabilizationMlh1 mediates tissue-specific regulation of mitotic recombinationRMI1 deficiency in mice protects from diet and genetic-induced obesityThe Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineageMutagenesis in rodents using the L1 retrotransposonBLM helicase facilitates telomere replication during leading strand synthesis of telomeresThe Bloom's syndrome helicase suppresses crossing over during homologous recombinationRecQ helicases: caretakers of the genomeSrs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast
P2860
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P2860
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
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2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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name
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@ast
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@en
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@nl
type
label
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@ast
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@en
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@nl
prefLabel
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@ast
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@en
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@nl
P2093
P2860
P3181
P356
P1433
P1476
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
@en
P2093
McDaniel LD
Nishijima I
Santoro IM
Schultz RA
Youssoufian H
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P2888
P304
P3181
P356
10.1038/82548
P407
P577
2000-12-01T00:00:00Z