A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
about
Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regionsLGI1 mutations in autosomal dominant partial epilepsy with auditory features.Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory featuresRefined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1Genetic epilepsy syndromes without structural brain abnormalities: clinical features and experimental modelsLGI proteins in the nervous system.MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell linesWAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastomaThe LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteinsLGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizuresAutosomal dominant lateral temporal epilepsy: two families with novel mutations in the LGI1 geneLGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathwayAbnormal phonologic processing in familial lateral temporal lobe epilepsy due to a new LGI1 mutationAdam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signalingDISIS: prediction of drug response through an iterative sure independence screeningLGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotypeLoss of zebrafish lgi1b leads to hydrocephalus and sensitization to pentylenetetrazol induced seizure-like behavior.The temporal and spatial expression pattern of the LGI1 epilepsy predisposition gene during mouse embryonic cranial development.Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice.Alterations in Barrett's-related adenocarcinomas: a proteomic approach.Inactivation of LGI1 expression accompanies early stage hyperplasia of prostate epithelium in the TRAMP murine model of prostate cancer.Reexpression of LGI1 in glioma cells results in dysregulation of genes implicated in the canonical axon guidance pathway.mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.Leucine-rich glioma inactivated 3: integrative analyses support its prognostic role in gliomaLgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitabilityA computational model of the LGI1 protein suggests a common binding site for ADAM proteins.A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case seriesIdentification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoproteinExpression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily.Combined analysis of genome-wide expression and copy number profiles to identify key altered genomic regions in cancer.Genomic profiling of peripheral T-cell lymphoma, unspecified, and anaplastic large T-cell lymphoma delineates novel recurrent chromosomal alterationsGenetic mechanisms that underlie epilepsy.Genetic pathways to primary and secondary glioblastomaExpression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1.Sacred disease secrets revealed: the genetics of human epilepsy.Genetic focal epilepsies: state of the art and paths to the future.LGI Proteins and Epilepsy in Human and AnimalsSchizophrenia and epilepsy: is there a shared susceptibility?
P2860
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P2860
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@ast
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@en
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@en-gb
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@nl
type
label
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@ast
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@en
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@en-gb
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@nl
prefLabel
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@ast
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@en
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@en-gb
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@nl
P2093
P921
P356
P1433
P1476
A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
@en
P2093
J K Cowell
O B Chernova
R P Somerville
P2888
P304
P356
10.1038/SJ.ONC.1202481
P407
P577
1998-12-03T00:00:00Z
P5875
P6179
1052591362