WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma
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Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.Role of the WASP and WAVE family proteins in breast cancer invasion and metastasisWAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinaseCytoskeletal dynamics and spermatogenesis.Inactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastases.Surfing the big WAVE: Insights into the role of WAVE3 as a driving force in cancer progression and metastasisIncreased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer.Evaluating human cancer cell metastasis in zebrafish.Knockdown of WAVE3 impairs HGF induced migration and invasion of prostate cancer cellsDown-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cellsCrk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.Regulation of the actin cytoskeleton in cancer cell migration and invasion.HIF1A induces expression of the WASF3 metastasis-associated gene under hypoxic conditions.Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein.Targeting the WASF3-CYFIP1 Complex Using Stapled Peptides Suppresses Cancer Cell Invasion.WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signalingCritical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility.The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasionWASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cellsThe involvement of JAK-STAT3 in cell motility, invasion, and metastasis.p63α protein upregulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion.Stapled peptides: providing the best of both worlds in drug development.Loss of WAVE3 sensitizes triple-negative breast cancers to chemotherapeutics by inhibiting the STAT-HIF-1α-mediated angiogenesis.The WAVE3-YB1 interaction regulates cancer stem cells activity in breast cancer.The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer.
P2860
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P2860
WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma
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2002 nî lūn-bûn
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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@ast
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@en
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@nl
type
label
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@ast
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@en
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@nl
prefLabel
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@ast
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@en
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@nl
P2093
P2860
P356
P1433
P1476
WAVE3, an actin-polymerization ...... ient with ganglioneuroblastoma
@en
P2093
Guanfang Su
John K Cowell
Khalid Sossey-Alaoui
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205734
P407
P577
2002-08-29T00:00:00Z
P5875
P6179
1027897885