KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
about
Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversityCellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndromeA carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss.Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channelTMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner earStructural insight into KCNQ (Kv7) channel assembly and channelopathyInhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptorsCharacterization of KCNQ5/Q3 potassium channels expressed in mammalian cellsInactivation as a new regulatory mechanism for neuronal Kv7 channelsKCNQ potassium channels in sensory system and neural circuitsNeuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and PitfallsThe role of connexins in ear and skin physiology - functional insights from disease-associated mutationsNew and emerging treatments for epilepsy: review of clinical studies of lacosamide, eslicarbazepine acetate, ezogabine, rufinamide, perampanel, and electrical stimulation therapyDriving with no brakes: molecular pathophysiology of Kv7 potassium channelsStructure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-Helix Complex Provides Insight into M Current ModulationDistinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channelsKCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currentsLIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in miceIon channels and epilepsyFunctional significance of K+ channel β-subunit KCNE3 in auditory neuronsComplete loss of the cytoplasmic carboxyl terminus of the KCNQ2 potassium channel: a novel mutation in a large Czech pedigree with benign neonatal convulsions or other epileptic phenotypesFunctional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytesArrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death.Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channelsTwo open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channelsLead roles for supporting actors: critical functions of inner ear supporting cellsThe acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytesSubcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heartK(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cellsDual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinaseMolecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscleTargeted disruption of otog results in deafness and severe imbalanceMice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing lossThe voltage-gated potassium channel subfamily KQT member 4 (KCNQ4) displays parallel evolution in echolocating bats.Parallel evolution of KCNQ4 in echolocating batsFinding new genes for non-syndromic hearing loss through an in silico prioritization studyThe structural and functional differentiation of hair cells in a lizard's basilar papilla suggests an operational principle of amniote cochleas.Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
P2860
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P2860
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@ast
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@en
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@en-gb
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@nl
type
label
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@ast
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@en
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@en-gb
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@nl
prefLabel
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@ast
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@en
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@en-gb
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@nl
P2093
P50
P3181
P1433
P1476
KCNQ4, a novel potassium chann ...... s mutated in dominant deafness
@en
P2093
B C Schroeder
B Lütjohann
T Friedrich
P304
P3181
P356
10.1016/S0092-8674(00)80556-5
P407
P577
1999-02-01T00:00:00Z