Targeted disruption of otog results in deafness and severe imbalance
about
Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear.Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues.Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeatThe nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner earFdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchymeOtolith tethering in the zebrafish otic vesicle requires Otogelin and α-TectorinA phylomedicine approach to understanding the evolution of auditory sensory perception and disease in mammalsExtracellular matrices associated with the apical surfaces of sensory epithelia in the inner ear: Molecular and structural diversitySharpened cochlear tuning in a mouse with a genetically modified tectorial membrane.Otolithic membrane damage in patients with endolymphatic hydrops and drop attacksModified protein expression in the tectorial membrane of the cochlea reveals roles for the striated sheet matrix.Similar phenotypes caused by mutations in OTOG and OTOGL.Inner ear supporting cells: rethinking the silent majority.Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants.Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.Molecular biology of hearing.Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation.Signatures from tissue-specific MPSS libraries identify transcripts preferentially expressed in the mouse inner ear.Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrixLongitudinally propagating traveling waves of the mammalian tectorial membrane.The tectorial membrane: one slice of a complex cochlear sandwichFunction and expression pattern of nonsyndromic deafness genesOtoconin-90 deletion leads to imbalance but normal hearing: a comparison with other otoconia mutantsEvidence and implications of inhomogeneity in tectorial membrane elasticity.A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear.The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gammaCalcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation.Transgenic and gene targeting studies of hair cell function in mouse inner ear.Poroelastic bulk properties of the tectorial membrane measured with osmotic stressDevelopment of vestibular afferent projections into the hindbrain and their central targets.Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear.Molecular conservation and novelties in vertebrate ear development.Mechanisms of otoconia and otolith developmentMixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial developmentA new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairmentMutations of the gene encoding otogelin are a cause of autosomal-recessive nonsyndromic moderate hearing impairmentMutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss.
P2860
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P2860
Targeted disruption of otog results in deafness and severe imbalance
description
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 2000
@ast
im Februar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/02/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/02/01)
@nl
наукова стаття, опублікована в лютому 2000
@uk
name
Targeted disruption of otog results in deafness and severe imbalance
@ast
Targeted disruption of otog results in deafness and severe imbalance
@en
Targeted disruption of otog results in deafness and severe imbalance
@nl
type
label
Targeted disruption of otog results in deafness and severe imbalance
@ast
Targeted disruption of otog results in deafness and severe imbalance
@en
Targeted disruption of otog results in deafness and severe imbalance
@nl
prefLabel
Targeted disruption of otog results in deafness and severe imbalance
@ast
Targeted disruption of otog results in deafness and severe imbalance
@en
Targeted disruption of otog results in deafness and severe imbalance
@nl
P2093
P2860
P50
P356
P1433
P1476
Targeted disruption of otog results in deafness and severe imbalance
@en
P2093
Benichou JC
Guillaud L
Simmler MC
P2860
P2888
P304
P356
10.1038/72793
P407
P577
2000-02-01T00:00:00Z