Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly
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The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenasePEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein importPEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesisMolecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10pDefective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group GTopogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments. study using human membrane protein PMP34Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomesIn vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19pPEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteinsPhosphomevalonate kinase is a cytosolic protein in humansCharacterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interactionThe membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assemblyStructural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3pPeroxisomes are signaling platforms for antiviral innate immunityThe peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathwayPEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteinsThe peroxisomal receptor Pex19p forms a helical mPTS recognition domainInteraction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphatePEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G.PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders.The peroxin pex3p initiates membrane assembly in peroxisome biogenesisHuman pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequencesPeroxisomes in brain development and functionPeroxisome biogenesis in mammalian cellsAssociation between the intrinsically disordered protein PEX19 and PEX3Insights into Peroxisome Function from the Structure of PEX3 in Complex with a Soluble Fragment of PEX19Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic ReticulumThe dynamin-like protein Vps1p of the yeast Saccharomyces cerevisiae associates with peroxisomes in a Pex19p-dependent manner.Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner.Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.Pex30p, Pex31p, and Pex32p form a family of peroxisomal integral membrane proteins regulating peroxisome size and number in Saccharomyces cerevisiae.Yeast peroxisomes multiply by growth and division.Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteinsCatalase-less peroxisomes. Implication in the milder forms of peroxisome biogenesis disorderPotential role for Pex19p in assembly of PTS-receptor docking complexesDomain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteinsThe peroxisome: still a mysterious organelleTopogenesis and homeostasis of fatty acyl-CoA reductase 1Coupling organelle inheritance with mitosis to balance growth and differentiationGlycosome biogenesis in trypanosomes and the de novo dilemma.
P2860
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P2860
Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@ast
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@en
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@en-gb
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@nl
type
label
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@ast
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@en
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@en-gb
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@nl
prefLabel
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@ast
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@en
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@en-gb
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@nl
P2093
P2860
P356
P1476
Human PEX19: cDNA cloning by f ...... peroxisomal membrane assembly
@en
P2093
M Hamasaki
N Kinoshita
N Shimozawa
R J Wanders
Y Matsuzono
P2860
P304
P356
10.1073/PNAS.96.5.2116
P407
P577
1999-03-02T00:00:00Z