Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2
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Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosisThe structure of human 15-lipoxygenase-2 with a substrate mimicInverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epitheliaThe role of lipoxygenases in pathophysiology; new insights and future perspectivesStructure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ RegulationMammalian lipoxygenases and their biological relevanceSystematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesiaSequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesisLipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoformsThe N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation.Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.Mutagenesis and modelling of linoleate-binding to pea seed lipoxygenase.Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancerThematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generationIdentification of the Substrate Access Portal of 5-LipoxygenaseDietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancerControl of oxygenation in lipoxygenase and cyclooxygenase catalysisEvolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxinsInteraction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular diseaseFunctional characterization of genetic enzyme variations in human lipoxygenases.Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation.Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites.The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy.Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept.A bisallylic mini-lipoxygenase from cyanobacterium Cyanothece sp. that has an iron as cofactor.Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSISPPARs and lipid ligands in inflammation and metabolism.Applicability of the triad concept for the positional specificity of mammalian lipoxygenases.Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino acid.Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality.Computational insight into the catalytic implication of head/tail-first orientation of arachidonic acid in human 5-lipoxygenase: consequences for the positional specificity of oxygenation.
P2860
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P2860
Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@ast
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@en
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@en-gb
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@nl
type
label
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@ast
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@en
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@en-gb
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@nl
prefLabel
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@ast
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@en
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@en-gb
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@nl
P2093
P921
P356
P1476
Identification of amino acid d ...... e and human 15S-lipoxygenase-2
@en
P2093
P304
P356
10.1074/JBC.275.2.1287
P407
P577
2000-01-14T00:00:00Z