Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia - Test2 - elhamkhani - TriplyDB

Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia

Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia

http://www.wikidata.org/entity/Q24550862

about

The role of lipoxygenases in pathophysiology; new insights and future perspectives A review of the past, present, and future directions of neoplasia Neoplasia: Where We Have Been and Where We Are Going Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma.Glutamine activates peroxisome proliferator-activated receptor-γ in intestinal epithelial cells via 15-S-HETE and 13-OXO-ODE: a novel mechanism What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells Synergistic interaction between PPAR ligands and salbutamol on human bronchial smooth muscle cell proliferation Chemotherapeutic drugs induce PPAR-gamma expression and show sequence-specific synergy with PPAR-gamma ligands in inhibition of non-small cell lung cancer A Role for the PPARgamma in Cancer Therapy.Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.Roles of Eicosanoids in Prostate Cancer.Synergistic Antiproliferative Effects of Combined γ -Tocotrienol and PPAR γ Antagonist Treatment Are Mediated through PPAR γ -Independent Mechanisms in Breast Cancer Cells.Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention.PPAR gamma, bioactive lipids, and cancer progression.Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling.Antineoplastic effects of 15(S)-hydroxyeicosatetraenoic acid and 13-S-hydroxyoctadecadienoic acid in non-small cell lung cancer.Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.Gamma tocopherol upregulates the expression of 15-S-HETE and induces growth arrest through a PPAR gamma-dependent mechanism in PC-3 human prostate cancer cells.Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer.Synergistic effect of 15-lipoxygenase 2 and radiation in killing head-and-neck cancer.Neoplasia: An Anniversary of Progress.Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities

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P2860

Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia

http://www.wikidata.org/entity/Q24550862

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Anita L Sabichi

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Ashraful Hoque

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Christopher J Logothetis

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David G Menter

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Gabriella Mendoza

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Robert A Newman

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P2860

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells

Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells

Discovery of a second 15S-lipoxygenase in humans

Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene

The mechanisms of action of PPARs

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