Cloning and characterization of a novel human dual flavin reductase
about
Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalaminsDecyanation of vitamin B12 by a trafficking chaperoneNADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transferStructure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesNADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.The P450 oxidoreductase, RedA, controls development beyond the mound stage in Dictyostelium discoideum.Modulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer.Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1.Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.Engineering of a functional human NADH-dependent cytochrome P450 systemReversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liverControl of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.Restricted role for methionine synthase reductase defined by subcellular localization.Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.Dynamic control of electron transfers in diflavin reductases.Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase.Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function.Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP(+) oxidoreductase and pyruvate formate-lyase activating enzyme.Decrease in NADPH-cytochrome P450 reductase activity of the human heart, Liver and lungs in the presence of alpha-lipoic acid.Binding of PDZ domains to the carboxy terminus of inducible nitric oxide synthase boosts electron transfer and NO synthesis.Requirements of the cytosolic iron-sulfur cluster assembly pathway in ArabidopsisDomain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.FMN binding site of yeast NADPH-cytochrome P450 reductase exposed at the surface is highly specificStopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase.Pyruvate : NADP+ oxidoreductase from the mitochondrion of Euglena gracilis and from the apicomplexan Cryptosporidium parvum: a biochemical relic linking pyruvate metabolism in mitochondriate and amitochondriate protists.Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains.Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain.Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395.Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes.Distinguishing two groups of flavin reductases by analyzing the protonation state of an active site carboxylic acid.Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex.Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs
P2860
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P2860
Cloning and characterization of a novel human dual flavin reductase
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Cloning and characterization of a novel human dual flavin reductase
@ast
Cloning and characterization of a novel human dual flavin reductase
@en
Cloning and characterization of a novel human dual flavin reductase
@en-gb
Cloning and characterization of a novel human dual flavin reductase
@nl
type
label
Cloning and characterization of a novel human dual flavin reductase
@ast
Cloning and characterization of a novel human dual flavin reductase
@en
Cloning and characterization of a novel human dual flavin reductase
@en-gb
Cloning and characterization of a novel human dual flavin reductase
@nl
prefLabel
Cloning and characterization of a novel human dual flavin reductase
@ast
Cloning and characterization of a novel human dual flavin reductase
@en
Cloning and characterization of a novel human dual flavin reductase
@en-gb
Cloning and characterization of a novel human dual flavin reductase
@nl
P2093
P356
P1476
Cloning and characterization of a novel human dual flavin reductase
@en
P2093
A P Garner
P304
P356
10.1074/JBC.275.2.1471
P407
P577
2000-01-14T00:00:00Z