Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450
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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiencyStructural diversity of eukaryotic membrane cytochrome p450sConformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor BindingStructural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenaseStructural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate–Histidine Hydrogen BondCytochrome P450 17A1 Interactions with the FMN Domain of Its Reductase as Characterized by NMREpitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activityStructure and dynamics of the membrane-bound cytochrome P450 2C9Coupled motions direct electrons along human microsomal P450 ChainsKinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c.NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domainModulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer.Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect.Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicityMechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.Heme enzyme structure and function.Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactionsA kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.Real-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome cAltered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro systemSingle-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics.Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase.Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.Nanoscale electron transport measurements of immobilized cytochrome P450 proteins.Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and MetabolismMutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN SemiquinoneRegulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase.From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes.Dynamic control of electron transfers in diflavin reductases.Towards the free energy landscape for catalysis in mammalian nitric oxide synthases.Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase.Pyridine Dinucleotides from Molecules to Man.Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
P2860
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P2860
Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structure and Function of an N ...... le of Reducing Cytochrome P450
@ast
Structure and Function of an N ...... le of Reducing Cytochrome P450
@en
Structure and Function of an N ...... le of Reducing Cytochrome P450
@nl
type
label
Structure and Function of an N ...... le of Reducing Cytochrome P450
@ast
Structure and Function of an N ...... le of Reducing Cytochrome P450
@en
Structure and Function of an N ...... le of Reducing Cytochrome P450
@nl
prefLabel
Structure and Function of an N ...... le of Reducing Cytochrome P450
@ast
Structure and Function of an N ...... le of Reducing Cytochrome P450
@en
Structure and Function of an N ...... le of Reducing Cytochrome P450
@nl
P2093
P2860
P356
P1476
Structure and Function of an N ...... le of Reducing Cytochrome P450
@en
P2093
Chuanwu Xia
Djemel Hamdane
Haoming Zhang
Jung-Ja P Kim
Lucy Waskell
Sang-Choul Im
P2860
P304
P356
10.1074/JBC.M807868200
P407
P577
2009-04-24T00:00:00Z