Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits
about
sameAs
Role of the UPS in Liddle syndromeIdentification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expressionMultiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channelInteraction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulationAlternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.Abnormal regulation of ENaC: syndromes of salt retention and salt wasting by the collecting duct.Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport.Regulation of the epithelial sodium channel by accessory proteinsAcute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool.Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1.Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface.A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.Roles of the C termini of alpha -, beta -, and gamma -subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+.Calcium rapidly down-regulates human renal epithelial sodium channels via a W-7-sensitive mechanism.RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channelsPKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1.Identification of Cytoplasmic Domains within the Epithelial Na+Channel Reactive at the Plasma Membrane
P2860
Q21284380-4F87AAFA-F026-4267-B63E-BC8203DF110CQ24532178-8D61CAC5-D0EF-4200-A772-ADAA4A109331Q24534668-6D47B42F-E1F1-4941-95A5-66B3D68EEBD9Q28189718-1EBBF425-E8B3-44C9-83DB-FF1802F0FFF5Q28217136-2C644324-AB94-4F8B-9D48-56518DD1E12BQ33668782-B7C76B04-736C-448B-B73E-7417473AD8BCQ34216316-22776BE6-32DB-4B7D-92B4-83099CCA5C22Q34731561-895805AD-EBAD-4D69-BBDD-8DD500AB779DQ34777003-5F17FC24-A00E-452D-B65E-A43390CED371Q35013324-A83CAD3A-092C-4E86-8B5A-AFFF16443493Q36412575-9EA8DB66-75F8-44FC-BA3B-7AB1CE01C897Q36571577-1EC52347-FDFB-424D-A633-5F7CE1C04AA1Q36902198-D1193B57-CC6E-4D12-B13A-0F1E3AE54DB6Q40501781-DD962EAC-3CB9-4AEA-9D6C-92A782B934D0Q40735408-73FA4D26-045F-4A32-B185-7769BED2FED0Q42529026-CB019191-19B6-4B18-AFAE-1932794DA79CQ43000858-EDEB5146-3797-41A0-9822-E3E867EF2568Q43560000-61CA8E83-C26F-4B03-A31C-9261AA0D8184Q45718161-BEE14CD2-5B7A-4B58-9D5B-6100210D7C7FQ50299657-9BA2AD89-8D19-4EE7-A90F-2AC50CD1C853Q50964185-53BF2EF2-3195-4557-9551-0056D78713E6Q56504572-3DA6D97C-61AE-4D31-94FE-FEDB397CBC69
P2860
Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@ast
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@en
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@en-gb
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@nl
type
label
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@ast
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@en
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@en-gb
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@nl
prefLabel
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@ast
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@en
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@en-gb
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@nl
P2093
P2860
P921
P356
P1433
P1476
Human Nedd4 interacts with the ...... binds to Na+-channel subunits
@en
P2093
F J McDonald
P M Snyder
S J Coddington-Lawson
P2860
P356
10.1042/BJ3450503
P407
P478
P577
2000-02-01T00:00:00Z