Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression - Test2 - elhamkhani - TriplyDB

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression

http://www.wikidata.org/entity/Q24534668

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Nedd4-2 and the regulation of epithelial sodium transport The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs Role of the UPS in Liddle syndrome The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4 Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl COMMD1 downregulates the epithelial sodium channel through Nedd4-2 Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice Respiratory distress and perinatal lethality in Nedd4-2-deficient mice Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery The Epithelial Sodium Channel and the Processes of Wound Healing Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors Ubiquitylation and control of renal Na+ balance and blood pressure Defective interactions of protein partner with ion channels and transporters as alternative mechanisms of membrane channelopathies Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells Regulation of αENaC transcription The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport The epithelial sodium channel δ-subunit: new notes for an old song Organization of the ENaC-regulatory machinery Epigenetics and the control of the collecting duct epithelial sodium channel Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP-PNP Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)Regulation and dysregulation of epithelial Na+ channels Up-regulation of hypertonicity-activated myo-inositol transporter SMIT1 by the cell volume-sensitive protein kinase SGK1 Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2 Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channels Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2 Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner

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P2860

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression

http://www.wikidata.org/entity/Q24534668

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2001 nî lūn-bûn

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2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Phosphorylation of Nedd4-2 by ...... hannel cell surface expression

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Phosphorylation of Nedd4-2 by ...... hannel cell surface expression

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A Chraïbi

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C Debonneville

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C Münster

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J Loffing

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M A Thomas

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P2860

Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene

Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity

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4162727

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24

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11613783

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11742982

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phosphorylation

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125341

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