Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP
about
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivationDAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expressionRole of KLF15 in regulation of hepatic gluconeogenesis and metformin actionUp- and down-regulation of adiponectin expression and multimerization: mechanisms and therapeutic implicationRegulation of glucose metabolism from a liver-centric perspectiveOxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitusNuclear receptors and AMPK: resetting metabolismCellular and molecular mechanisms of metformin: an overviewMolecular mechanisms of insulin resistance in chronic hepatitis CHepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytesChlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetesSmall heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2Novel Approach to Identify Potential Bioactive Plant Metabolites: Pharmacological and Metabolomics Analyses of Ethanol and Hot Water Extracts of Several Canadian Medicinal Plants of the Cree of Eeyou IstcheeMetformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived XenograftsGenomic Characterization of Metformin Hepatic ResponseThe orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptorsRole of nuclear receptor SHP in metabolism and cancer.High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db miceMetformin to Augment Strength Training Effective Response in Seniors (MASTERS): study protocol for a randomized controlled trial.AMPK activation--protean potential for boosting healthspan.Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis.Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans.Standardized extract of Ficus deltoidea stimulates insulin secretion and blocks hepatic glucose production by regulating the expression of glucose-metabolic genes in streptozitocin-induced diabetic rats.Triterpenoid saponins from Stauntonia chinensis ameliorate insulin resistance via the AMP-activated protein kinase and IR/IRS-1/PI3K/Akt pathways in insulin-resistant HepG2 cellsCREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesisMetformin inhibits food intake and neuropeptide Y gene expression in the hypothalamusPharmacogenetics of Anti-Diabetes Drugs.AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention.Metformin improves healthspan and lifespan in mice.Nonalcoholic Fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective.Locating the source of hyperglycemia: liver versus muscleMild electrical stimulation increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway in C. elegans.Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway.Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agentEvidence of insulin resistance in adult uncomplicated malaria: result of a two-year prospective studySmall heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasomeCannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytesThe orphan nuclear receptor SHP is a positive regulator of osteoblastic bone formation.Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene
P2860
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P2860
Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@ast
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@en
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@en-gb
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@nl
type
label
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@ast
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@en
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@en-gb
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@nl
altLabel
Metformin inhibits hepatic glu ...... he orphan nuclear receptor SHP
@en
prefLabel
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@ast
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@en
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@en-gb
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@nl
P2093
P3181
P356
P1433
P1476
Metformin Inhibits Hepatic Glu ...... he Orphan Nuclear Receptor SHP
@en
P2093
B. Nedumaran
H.-S. Choi
K.-G. Park
W. G. Jang
P304
P3181
P356
10.2337/DB07-0381
P407
P577
2007-10-01T00:00:00Z