Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2
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Deficient expression of DNA repair enzymes in early progression to sporadic colon cancerMLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityEpigenetic field defects in progression to cancerDiffering patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cellsRates of spontaneous mutationMutation frequency and specificity with age in liver, bladder and brain of lacI transgenic miceMolecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesisCombined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancersmiR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB RepairMutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshiftsTumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repairElevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cellsElevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epitheliumDifferent mutator phenotypes in Mlh1- versus Pms2-deficient miceEffect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cellsPeptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotidesEvidence for a recessive inheritance of Turcot's syndrome caused by compound heterozygous mutations within the PMS2 gene.Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome.Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegansColorectal pretumor progression before and after loss of DNA mismatch repairTargeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugateTissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells.A novel DNA damage response mediated by DNA mismatch repair in Caenorhabditis elegans: induction of programmed autophagic cell death in non-dividing cells.Local delivery of gene-modifying triplex-forming molecules to the epidermis.An intact Pms2 ATPase domain is not essential for male fertilityTractable Cre-lox system for stochastic alteration of genes in miceDiscovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome.Keeping up with the Red Queen: the pace of aging as an adaptation.A triple-helix forming oligonucleotide targeting genomic DNA fails to induce mutation.Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair.Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells.Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.
P2860
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P2860
Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@ast
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@en
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@nl
type
label
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@ast
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@en
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@nl
prefLabel
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@ast
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@en
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@nl
P2093
P2860
P356
P1476
Elevated levels of mutation in ...... DNA mismatch repair gene Pms2
@en
P2093
J. A. Fritzell
L. Narayanan
P. M. Glazer
R. M. Liskay
S. M. Baker
P2860
P304
P356
10.1073/PNAS.94.7.3122
P407
P577
1997-04-01T00:00:00Z