Characterization of PDZ-binding kinase, a mitotic kinase
about
Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102HDLG5/KIAA0583, encoding a MAGUK-family protein, is a primary progesterone target gene in breast cancer cellsIdentification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteinsRegulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptorPBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large genep38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAPAnalysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinomeAn in silico analysis of the binding modes and binding affinities of small molecule modulators of PDZ-peptide interactionsThe distribution and function of alternatively spliced insertions in hDlg.Accidental interaction between PDZ domains and diclofenac revealed by NMR-assisted virtual screening.A high efficiency strategy for binding property characterization of peptide-binding domains.Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families.Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis.Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients.PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cellsThe MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring.T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arraysExpression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia.Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia modelCoffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPKTranscriptome analysis of the hormone-sensing cells in mammary epithelial reveals dynamic changes in early pregnancy.Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.Phosphorylation of IκBα at serine 32 by T-lymphokine-activated killer cell-originated protein kinase is essential for chemoresistance against doxorubicin in cervical cancer cells.Gossypol-Induced Differentiation in Human Leukemia HL-60 Cells.Screening for genes and subnetworks associated with pancreatic cancer based on the gene expression profilePBK/TOPK Expression Predicts Prognosis in Oral CancerPhosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colonCefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase.Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activityRadiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase.The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteins.PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion.Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma.PDZ binding kinase, regulated by FoxM1, enhances malignant phenotype via activation of β-Catenin signaling in hepatocellular carcinoma.The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H₂O₂-Induced Injury in H9C2 Cardiomyocytes.Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase
P2860
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P2860
Characterization of PDZ-binding kinase, a mitotic kinase
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Characterization of PDZ-binding kinase, a mitotic kinase
@ast
Characterization of PDZ-binding kinase, a mitotic kinase
@en
Characterization of PDZ-binding kinase, a mitotic kinase
@en-gb
Characterization of PDZ-binding kinase, a mitotic kinase
@nl
type
label
Characterization of PDZ-binding kinase, a mitotic kinase
@ast
Characterization of PDZ-binding kinase, a mitotic kinase
@en
Characterization of PDZ-binding kinase, a mitotic kinase
@en-gb
Characterization of PDZ-binding kinase, a mitotic kinase
@nl
prefLabel
Characterization of PDZ-binding kinase, a mitotic kinase
@ast
Characterization of PDZ-binding kinase, a mitotic kinase
@en
Characterization of PDZ-binding kinase, a mitotic kinase
@en-gb
Characterization of PDZ-binding kinase, a mitotic kinase
@nl
P2860
P921
P3181
P356
P1476
Characterization of PDZ-binding kinase, a mitotic kinase
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.090102397
P407
P577
2000-05-09T00:00:00Z