PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
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Disruption of Lipid Raft Function Increases Expression and Secretion of Monocyte Chemoattractant Protein-1 in 3T3-L1 AdipocytesRelationships between signaling pathway usage and sensitivity to a pathway inhibitor: examination of trametinib responses in cultured breast cancer linesA multi-omics approach identifies key hubs associated with cell type-specific responses of airway epithelial cells to staphylococcal alpha-toxin.Integration of protein abundance and structure data reveals competition in the ErbB signaling network.The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance.Sanguinarine inhibits growth and invasion of gastric cancer cells via regulation of the DUSP4/ERK pathway.IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma.Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae.Autocrine motility factor modulates EGF-mediated invasion signaling.Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling.Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways.Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells.Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.Heregulin negatively regulates transcription of ErbB2/3 receptors via an AKT-mediated pathwayPreclinical testing of PI3K/AKT/mTOR signaling inhibitors in a mouse model of ovarian endometrioid adenocarcinoma.Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP.Phosphatidylinositol Phosphate 5-Kinase Iγ and Phosphoinositide 3-Kinase/Akt Signaling Couple to Promote Oncogenic Growth.Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling.PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma.Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR.An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc AxisCannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors.Interferon gamma induces protective non-canonical signaling pathways in primary neuronsG-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors.Fibroblast growth factor receptor like-1 (FGFRL1) interacts with SHP-1 phosphatase at insulin secretory granules and induces beta-cell ERK1/2 protein activation.Akt-dependent activation of Erk by cyclin D1b contributes to cell invasiveness and tumorigenicityNetwork quantification of EGFR signaling unveils potential for targeted combination therapy.Role of EGF/ERBB1 in the transcriptional regulation of the prolactin receptor independent of estrogen and prolactin in breast cancer cells.Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kα-selective Inhibitors in Breast Cancer.Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability.Integrating network reconstruction with mechanistic modeling to predict cancer therapies.Modelling the molecular mechanisms of aging.Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells.Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.Female-specific rectal carcinogenesis in cyclin D1b transgenic mice.MAPK signaling has stage-dependent osteogenic effects on human adipose-derived stem cells in vitro.Single cell network profiling assay in bladder cancer.CCN3 regulates proliferation and migration properties in Jeg3 trophoblast cells via ERK1/2, Akt and Notch signalling.
P2860
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P2860
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
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2010年学术文章
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2010年學術文章
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name
PI3K/Akt-sensitive MEK-indepen ...... utant T47D breast cancer cells
@ast
PI3K/Akt-sensitive MEK-indepen ...... utant T47D breast cancer cells
@en
type
label
PI3K/Akt-sensitive MEK-indepen ...... utant T47D breast cancer cells
@ast
PI3K/Akt-sensitive MEK-indepen ...... utant T47D breast cancer cells
@en
prefLabel
PI3K/Akt-sensitive MEK-indepen ...... utant T47D breast cancer cells
@ast
PI3K/Akt-sensitive MEK-indepen ...... utant T47D breast cancer cells
@en
P2860
P50
P1433
P1476
PI3K/Akt-sensitive MEK-indepen ...... utant T47D breast cancer cells
@en
P2860
P304
P356
10.1016/J.CELLSIG.2010.05.006
P577
2010-05-12T00:00:00Z