Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III
about
beta-Amyloid degradation and Alzheimer's diseaseHuman and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase familyThe metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differencesThe beta subunit of the mitochondrial processing peptidase from rat liver: cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidasesMutational analysis of the potential catalytic residues of the VV G1L metalloproteinase.Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapiesA chloroplast processing enzyme involved in precursor maturation shares a zinc-binding motif with a recently recognized family of metalloendopeptidases.Homologues of insulinase, a new superfamily of metalloendopeptidases.Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors.N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes.An unusual active site identified in a family of zinc metalloendopeptidasesAmyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivoTn5-directed cloning of pqq genes from Pseudomonas fluorescens CHA0: mutational inactivation of the genes results in overproduction of the antibiotic pyoluteorin.Cloning and nucleotide sequence of opdA, the gene encoding oligopeptidase A in Salmonella typhimuriumAn evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulinSelective degradation of insulin within rat liver endosomes.A transcriptionally controlled trans-processing assay: putative identification of a vaccinia virus-encoded proteinase which cleaves precursor protein P25K.Next Generation Sequencing Identifies Five Major Classes of Potentially Therapeutic Enzymes Secreted by Lucilia sericata Medical MaggotsEffects of Alzheimer's amyloid-beta and tau protein on mitochondrial function -- role of glucose metabolism and insulin signalling.Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment.Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?Two novel metallopeptidases with a specificity for basic residues: functional properties, structure and cellular distribution.Identification of glutamate-169 as the third zinc-binding residue in proteinase III, a member of the family of insulin-degrading enzymes.Purification of a protease in red blood cells that degrades oxidatively damaged haemoglobin.Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.A common genetic system for functional studies of pitrilysin and related M16A proteases.Preparation and characterization of novel substrates of insulin proteinase (EC 3.4.99.45).Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells.N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface.Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease.Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts.Studies on the subsite specificity of rat nardilysin (N-arginine dibasic convertase).Multiple functions of insulin-degrading enzyme: a metabolic crosslight?Directed mutagenesis of pig renal membrane dipeptidase. His219 is critical but the DHXXH motif is not essential for zinc binding or catalytic activity.
P2860
Q21284467-1C9BD52D-0D47-4417-8153-A24DF3E1D5BDQ24314532-94BFA372-3B9B-48A0-81CA-7C60DED790D1Q24534617-791FABD5-46F7-40BB-92E0-9C1DBCFF2D10Q28201642-BA4CE93E-7E09-4174-A23F-D20468236D39Q28584294-4795417E-0700-4987-8AAF-B655B7F2E3F6Q33234918-4250DC61-25E0-445E-9F42-BA90F41F9019Q33735929-A714B2F7-8CA8-4864-AEC1-40137F358076Q34033509-2AE4C703-F3BE-44FC-B1CF-CD58DF0EF60DQ34104644-1A83C245-7AEC-43CD-8CDE-DD9917382863Q34130712-F0BE1525-29C8-4AC5-B649-3A7B4E8ADF4AQ34329161-30A55618-C855-400A-A318-90F9964E2297Q34392671-3DAE20F8-F44B-4096-825B-017FA48DBF66Q34777829-031A1285-5D3D-408D-B3E4-FCD839F48161Q35023290-FAB12862-AA0E-47D1-9E16-938F012301BAQ35186847-FD7CDFB2-767E-4117-B930-CEB040040212Q36120498-090EF3E2-CE34-4E01-BE6C-0A58C4B6D8E4Q36221404-D120EF60-10D4-4BD8-ABC0-A74148B07C3AQ36222374-B241C308-64E9-4963-8F12-F3BE4A53EB42Q36637444-34A9B357-0F8E-4CFF-9205-91C2EE338242Q36784772-22E45FE3-7F9C-4673-9D81-9DB684FF4961Q36964574-DA25112C-651B-43ED-988E-07330CA4ACB5Q37569276-44C6DEEE-AB89-4C09-9878-C12AFB433C25Q38869928-8A251AA4-DCC8-4099-AA60-2E8AB539CBF5Q40970971-3F893478-90B9-4909-A55A-8087F05F534FQ42077584-716A0877-BC86-48C3-9EB8-B39FD1A8DCE9Q42161855-ECC220DB-AD05-4C65-A4C4-4DCE1DE91416Q42268455-4B500859-24DF-4F6B-92FD-0854223CD1F6Q42415956-403B46F6-2408-4212-8609-EDC07F701C72Q42829359-20C31033-8F7E-49C4-B4EF-A016F23C85D9Q42983966-778AD1D6-135D-4157-84D6-A714547A1DFCQ42997083-50AFB89C-2E8E-425D-A901-F3CE39923134Q44446906-3E1CFFE8-C3F0-4F66-BD0E-5DD9D5D30EBEQ48025908-4A097399-8C57-4965-9461-B7A804D7D44BQ48133008-83DA478F-E3B2-49F8-A9C9-CEDFAE7C2A4BQ48750839-CDA38A65-6C8C-4959-BDD1-8A6C02D14C5CQ50932512-C5A238DD-92F7-497A-8AF5-D6325BD728DFQ52871511-B7E6333F-8466-443C-B51F-42E6229D7DC5
P2860
Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III
description
1988 nî lūn-bûn
@nan
1988 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Human insulin-degrading enzyme ...... gies with E. coli protease III
@ast
Human insulin-degrading enzyme ...... gies with E. coli protease III
@en
Human insulin-degrading enzyme ...... gies with E. coli protease III
@en-gb
Human insulin-degrading enzyme ...... gies with E. coli protease III
@nl
type
label
Human insulin-degrading enzyme ...... gies with E. coli protease III
@ast
Human insulin-degrading enzyme ...... gies with E. coli protease III
@en
Human insulin-degrading enzyme ...... gies with E. coli protease III
@en-gb
Human insulin-degrading enzyme ...... gies with E. coli protease III
@nl
prefLabel
Human insulin-degrading enzyme ...... gies with E. coli protease III
@ast
Human insulin-degrading enzyme ...... gies with E. coli protease III
@en
Human insulin-degrading enzyme ...... gies with E. coli protease III
@en-gb
Human insulin-degrading enzyme ...... gies with E. coli protease III
@nl
P2093
P921
P3181
P356
P1433
P1476
Human insulin-degrading enzyme ...... gies with E. coli protease III
@en
P2093
J A Affholter
P304
P3181
P356
10.1126/SCIENCE.3059494
P407
P577
1988-12-09T00:00:00Z