DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas - Test2 - elhamkhani - TriplyDB

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

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TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages DLC-1: a Rho GTPase-activating protein and tumour suppressor Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2 '-deoxycytidine DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1 Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines Approaches of targeting Rho GTPases in cancer drug discovery Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer Deleted in liver cancer protein family in human malignancies (Review)Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion DLC1: a significant GAP in the cancer genome Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform Metastasis suppressor genes at the interface between the environment and tumor cell growth Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progression Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers Evaluation of surface water quality indices and ecological risk assessment for heavy metals in scrap yard neighbourhood Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphoma Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors.Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.The human orthologue of CdGAP is a phosphoprotein and a GTPase-activating protein for Cdc42 and Rac1 but not RhoA.Metastasis suppressors and the tumor microenvironment In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells Genomic alterations on 8p21-p23 are the most frequent genetic events in stage I squamous cell carcinoma of the lung

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P2860

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

http://www.wikidata.org/entity/Q23910292

description

2003 nî lūn-bûn

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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@ast

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@en

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@en-gb

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@nl

type

label

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@ast

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@en

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@en-gb

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@nl

prefLabel

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@ast

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@en

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@en-gb

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

@nl

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DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

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P2093

Amy M Jefferson

http://www.w3.org/2001/XMLSchema#string

Bao-Zhu Yuan

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Kimberly T Baldwin

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Nicholas C Popescu

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Snorri S Thorgeirsson

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P2860

The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

Review of occupational lung carcinogens.

Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers.

DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells

Antioncogenes and human cancer.

A role for Rho in Ras transformation.

p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.

Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.

Molecular genetic abnormalities in premalignant lung lesions: biological and clinical implications.

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20024285

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1405-1411

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scholarly article

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1851883

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10.1038/SJ.ONC.1207291

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7

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23

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Steven H. Reynolds

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2003-12-08T00:00:00Z

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8971755

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1003827126

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14661059

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National Institute for Occupational Safety and Health

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DNA methylation