DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms
about
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasisp120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activitiesDeleted in liver cancer-1 (DLC1): an emerging metastasis suppressor geneRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Cooperative antiproliferative effect of coordinated ectopic expression of DLC1 tumor suppressor protein and silencing of MYC oncogene expression in liver cancer cells: Therapeutic implicationsDLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinomaDLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activityMicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancerEffects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migrationDeleted in liver cancer protein family in human malignancies (Review)Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2ADLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanismThe Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarityTranscriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cellsCRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growthROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasionDLC1: a significant GAP in the cancer genomeRole of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motilityDLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domainDLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathwayIdentification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoformRole of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progressionDlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activationDifferential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformationFunctional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine fingerDLC1 is the principal biologically-relevant down-regulated DLC family member in several cancersSpatial regulation of RhoC activity defines protrusion formation in migrating cellsForces shaping a Hox morphogenetic gene network.Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinomaDeleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivoCDK5 is a major regulator of the tumor suppressor DLC1In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cellsEZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human CancersA Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging PhenotypesERK5 promotes Src-induced podosome formation by limiting Rho activation.miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1Deleted in liver cancer-1 inhibits cell growth and tumorigenicity in human pancreatic cancerExpression of deleted in liver cancer 1 and plasminogen activator inhibitor 1 protein in ovarian carcinoma and their clinical significance
P2860
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P2860
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@ast
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@en
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@en-gb
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@nl
type
label
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@ast
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@en
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@en-gb
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@nl
prefLabel
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@ast
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@en
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@en-gb
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@nl
P2093
P2860
P3181
P356
P1476
DLC-1 suppresses non-small cel ...... ent and independent mechanisms
@en
P2093
Adam Shutes
Channing J Der
Kevin D Healy
Klaus M Hahn
Louis Hodgson
Rudolph L Juliano
Savitri Maddileti
T Kendall Harden
Tai-Young Kim
Yung-Jue Bang
P2860
P304
P3181
P356
10.1002/MC.20389
P407
P577
2008-05-01T00:00:00Z