DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms - Test2 - elhamkhani - TriplyDB

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

http://www.wikidata.org/entity/Q24297480

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The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Cooperative antiproliferative effect of coordinated ectopic expression of DLC1 tumor suppressor protein and silencing of MYC oncogene expression in liver cancer cells: Therapeutic implications DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration Deleted in liver cancer protein family in human malignancies (Review)Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion DLC1: a significant GAP in the cancer genome Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progression Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers Spatial regulation of RhoC activity defines protrusion formation in migrating cells Forces shaping a Hox morphogenetic gene network.Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo CDK5 is a major regulator of the tumor suppressor DLC1 In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes ERK5 promotes Src-induced podosome formation by limiting Rho activation.miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1 Deleted in liver cancer-1 inhibits cell growth and tumorigenicity in human pancreatic cancer Expression of deleted in liver cancer 1 and plasminogen activator inhibitor 1 protein in ovarian carcinoma and their clinical significance

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DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

http://www.wikidata.org/entity/Q24297480

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2008 nî lūn-bûn

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2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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Molecular Carcinogenesis

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DLC-1 suppresses non-small cel ...... ent and independent mechanisms

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Adam Shutes

http://www.w3.org/2001/XMLSchema#string

Channing J Der

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Kevin D Healy

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Klaus M Hahn

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Louis Hodgson

http://www.w3.org/2001/XMLSchema#string

Rudolph L Juliano

http://www.w3.org/2001/XMLSchema#string

Savitri Maddileti

http://www.w3.org/2001/XMLSchema#string

T Kendall Harden

http://www.w3.org/2001/XMLSchema#string

Tai-Young Kim

http://www.w3.org/2001/XMLSchema#string

Yung-Jue Bang

http://www.w3.org/2001/XMLSchema#string

P2860

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers.

DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Rho GTPases in cell biology

Genomic analysis of metastasis reveals an essential role for RhoC

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326-37

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scholarly article

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4846373

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10.1002/MC.20389

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5

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47

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5912181

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17932950

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GTPase activator activity

DLC1 Rho GTPase activating protein

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2679972

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